| Source of record | UK Clinical Trials Gateway |
| ISRCTN | ISRCTN06298974 |
| Date ISRCTN assigned | 28/09/2007 |
| Local reference number(s) | N0019189543 |
| Public title | Pilot Study to test the usefulness of contractile reserve during dobutamine and exercise echo to predict recovery after mitral valve repair mitral valve prolapse |
| Scientific title |
|
| Acronym | N/A |
| Disease/condition/study domain | Cardiovascular: Mitral valve disease |
| Study hypothesis | To assess usefulness of contractile reserve during dobutamine and exercise echo to predict recovery after mitral valve repair for mitral valve prolapse. Whether contractile reserve judged by stress echocardiography, both pharmacological and exercise, can accurately predict post-operative exercise performance as judged by metabolic exercise performance following valve repair for mitral valve prolapse. |
| Design/methodology | Randomised controlled pilot study |
| Research ethics review | Not provided at time of registration |
| Countries of trial | United Kingdom |
| Participants - inclusion criteria | 1. Patients admitted to Eastbourne District General Hospital for mitral valve repair
2. Accepted for repair of mitral valve prolapse on clinical grounds and high probability of repairable valve |
| Participants - exclusion criteria | 1. Inability to perform test
2. Hypersensitivity to dobutamine or SonoView |
| Patient information material |
|
| Anticipated start date | 07/03/2007 |
| Anticipated end date | 01/05/2007 |
| Status of trial | Completed |
| Target number of participants | 15 |
| Interventions | Randomised Controlled Study |
| Primary outcome measure(s) | Death, myocardial infarction, hospitalisation for CHF. |
| Secondary outcome measure(s) | Baseline tissue Doppler contractile reserve, baseline exercise test parameters, neurohumoral markers, TOE and surgical parameters. |
| Sources of funding | East Sussex Hospitals NHS Trust
Peer Medical Research Trust
|
| Sponsor name | Record Provided by the NHSTCT Register - 2007 Update - Department of Health |
| Sponsor details | The Department of Health, Richmond House, 79 Whitehall
London
United Kingdom
SW1A 2NL |
| Sponsor telephone | +44 (0)20 7307 2622 |
| Sponsor fax | +44 |
| Sponsor email | dhmail@doh.gsi.org.uk |
| Sponsor website | http://www.dh.gov.uk/Home/fs/en |
| Contact name | Dr Guy Lloyd |
| Contact details | Cardiology
Eastbourne District General Hospital
Kings Drive
Eastbourne
United Kingdom
BN21 2UD |
| More information | For more up-to-date information please go to the ISRCTN link below. |
| Link to record in ISRCTN Register | ISRCTN06298974 |
| Date last extracted from ISRCTN register | 17/04/2008 |
