| Source of record | UK Clinical Trials Gateway |
| ISRCTN | ISRCTN25577630 |
| Date ISRCTN assigned | 30/09/2004 |
| Local reference number(s) | N0116135566 |
| Public title | Would continued ventilation during cardiopulmonary bypass reduce lung complications following cardiac surgery? |
| Scientific title |
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| Acronym | N/A |
| Disease/condition/study domain | Surgery: Cardiovascular |
| Study hypothesis | In order to answer the research question above the study has the following specific research aims. For selected patients undergoing cardiac surgery and randomised into either a group that is ventilated on bypass or a group that is not, to measure and compare between the two groups:
a. Pulmonary gas exchange
b. Lung mechanics
c. The activation of "inflammatory" pathways within the lungs
d. The presence of increased pulmonary vascular endothelial permeability
e. The presence of other evidence for pulmonary vascular endothelial damage or lung epithelial injury |
| Design/methodology | Randomised controlled trial |
| Research ethics review | Not provided at time of registration |
| Countries of trial | United Kingdom |
| Participants - inclusion criteria | Not provided at time of registration |
| Participants - exclusion criteria | Not provided at time of registration |
| Patient information material |
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| Anticipated start date | 01/09/2003 |
| Anticipated end date | 01/08/2004 |
| Status of trial | Completed |
| Target number of participants | Not provided at time of registration |
| Interventions | Randomised to a group that is ventilated on cardiopulmonary bypass or a group that is not. |
| Primary outcome measure(s) | Not provided at time of registration |
| Secondary outcome measure(s) | Not provided at time of registration |
| Sources of funding | Kings College Hospital NHS Trust R&D Consortium |
| Sponsor name | Record Provided by the NHSTCT Register - 2004 Update - Department of Health (UK) |
| Sponsor details | The Department of Health, Richmond House, 79 Whitehall
London
United Kingdom
SW1A 2NL |
| Sponsor telephone | +44 (0)20 7307 2622 |
| Sponsor email | dhmail@doh.gsi.org.uk |
| Sponsor website | http://www.dh.gov.uk/Home/fs/en |
| Contact name | Mr LCH John |
| Contact details | Cardiothoracic Surgery
King's College Hospital
London
United Kingdom
SE5 9RS |
| Contact email | lindsay.john@kingsch.nhs.uk |
| More information | For more up-to-date information please go to the ISRCTN link below. |
| Link to record in ISRCTN Register | ISRCTN25577630 |
| Date last extracted from ISRCTN register | 17/04/2008 |
