| Source of record | National Research Register |
| Serial number at source | N0162044641 |
| Project title | Randomised trial of radiotherapy v no further treatment after complete remission in nodular sclerosing Hodgkin's disease |
| Current status of trial | Ongoing |
| Main research question | To establish whether low dose radiotherapy improves remission duration in patients with nodular sclerosing histology in Hodgkin's disease and when the bulky disease at presentation represents most of the disease (stage 11 or 111), as found in sub-group analysis in American study (1994) |
| Design/methodology | Referral of patients by haematologists or oncologists who are treating patients with Hodgkin's disease with a standard chemo protocol who achieve a complete remission of the disease as judgd by both clinical and radiological criteria. Randomisation of patient between no further treatment at that time or radiotherapy to the sites of disease at presentation. Dose of radiotherapy 35 Gy in 20 fraction in four weeks encompassing the site(s) of initial bulk disease. |
| Sample group description | Patients with Hodgkin's disease who have completed complete remission with chemotherapy. male and female aged 16 years or over. |
| Multi-centre trial? | This is not a multi-centre trial. |
| Outcome measure | Endpoints are time to relapse at site(s) of original nodal disease, time to relapse at any site and overall survival. |
| Start date | 03/01/1998 |
| End date | 03/01/2008 |
| Primary keywords | HODGKIN-DISEASE Q-radiotherapy |
| Secondary keywords | RANDOMIZED-CONTROLLED-TRIAL; CLINICAL-TRIAL; RADIATION-DOSAGE; HUMAN; MALE; FEMALE |
| Region | South East Regional Office |
| NRR Data Provider | Northampton General Hospital NHS Trust |
| Funding organisation: name 1 | none |
| Contact name(s) | Dr Eric Bessell |
| Contact details | Dept Clinical Oncology
Nottingham City Hospital NHS Trust
Hucknall Rd
Nottingham
NG5 1PB
UK
Tel: 0115 967 0670
Fax: 0115 962 7994 |
| Further information | This record was taken from the National Research Register 2003, Issue 1, published in February 2003. Further information about this trial can be obtained from the lead researcher named above. |
| Date live in mRCT | 6 February 2003 |
