| Source of record | National Research Register |
| Serial number at source | N0547060854 |
| Project title | CML IV - An MRC prospective randomised study to compare interferon a n1 (wellferon) against 'IDAC' chemotherapy and autografting followed by interferon a n1 in patients with newly diagnosed chronic phase myeloid leukaemia. |
| Current status of trial | Complete |
| Main research question | How does interferon (Wellferon) compare with chemotherapy and autografting followed by Interferon (Wellferon) in patients with newly diagnosed chronic phase chronic myeloid leukaemia |
| Design/methodology | The aim of the trial is to attempt to improve on the best current therapy in chronic phase CML for those patients who do not undergo allogeneic bone marrow transplantation. The two arms of the trial will therefore compare interferon alpha (IFN) maintenance therapy alone against a cycle of high dose chemotherapy followed by an autograft and then IFN maintenance therapy |
| Sample group description | Data from both MRC and ECOG-recruited patients will be jointly analysed |
| Multi-centre trial? | This is not a multi-centre trial. |
| Outcome measure | length of survival, quality of life, cytogenetic response |
| Start date | 04/01/1995 |
| End date | 04/01/2000 |
| Primary keywords | LEUKEMIA-MYELOID-CHRONIC-PHASE Q-drug-therapy; INTERFERON-ALPHAQ-therapeutic-use; BONE-MARROW-TRANSPLANTATION Q-methods; ANTINEOPLASTIC-AGENTS Q-therapeutic-use |
| Secondary keywords | HUMAN; RANDOMIZED-CONTROLLED-TRIAL; CLINICAL-TRIAL; QUALITY-OF-LIFE; PROSPECTIVE-STUDIES; SURVIVAL-ANALYSIS |
| Region | Eastern Regional Office |
| NRR Data Provider | East Norfolk and Waveney Research Consortium - Norfolk and Norwich University Hospital/Norwich PCT |
| Contact name(s) | Dr Jennie Wimperis |
| Contact details | Consultant Haematologist
Haematology Department
Norfolk & Norwich University Hospital
Brunswick Road
Norwich
NR1 3SR
Tel: 01603 287866
Fax: 01603 286918 |
| Further information | This record was taken from the National Research Register 2003, Issue 1, published in February 2003. Further information about this trial can be obtained from the lead researcher named above. |
| Date live in mRCT | 6 February 2003 |
