| Source of record | NHS Trusts Clinical Trials Register - 2004 Update |
| ISRCTN | ISRCTN55568578 |
| Title of trial | Making Evidence-based Decisions Using Alzheimer Therapy (MEDUSA Therapy) |
| NHS Trust | Avon and Wiltshire Mental Health Partnership NHS Trust |
| Serial number at source/NRR Publication ID | N0038133699 |
| Local project reference | 0303AWP |
| Multicentre trial | No |
| Lead research centre | No |
| Start date | 30/09/2003 |
| End date | 01/12/2004 |
| Status | Completed |
| Disease or condition | Nervous System Diseases: Alzheimer's disease |
| Topic/hypothesis/clinical objectives | What evidence is there that altering therapy, after initial treatment starts to fail, will benefit the patient? |
| Inclusion criteria | 75 participants, (i.e. 15 in each arm of the trial) with diagnosis of Alzheimer's disease (AD) and aged between 55 and 95. |
| Exclusion criteria | Not available |
| Indicative number of participants | 75 |
| Randomised interventions | Randomised controlled trial (RCT):A. Cholinesterase inhibitor (ChEi) as usualB. Increased dose of ChEiC. RivastigmineD. MemantineE. ChEi as usual, plus memantine |
| Primary outcome measures | 1. Clinical Global Impression of Change (CGI/C)2. Mini-Mental State Examination (MMSE)3. BAYER-Activities of Daily Living (ADL)4. Neuropsychiatric inventory questionnaire (NPI-Q)5. Global Assessment Scale (GAS) |
| Secndary outcome measures | Not available |
| Sources of funding | Avon and Wiltshire Mental Health Partnership NHS Trust |
| Contact name | Dr Roger Bullock |
| Contact details | Kingshill Research Centre
Victoria Hospital
Okus Road
Swindon
SN1 4HZ
United Kingdom
Tel: +44 (0)1793 481182
Fax: +44 (0)1793 437521
Email: roger.bullock@kingshill-research.org |
| Primary MeSH keywords | DECISION-MAKING; EVIDENCE-BASED-MEDICINE; ALZHEIMER-DISEASE Q-drug-therapy; RIVASTIGMINE Q-administration-&-dosage; MEMANTINE Q-administration-&-dosage |
| Secondary MeSH keywords | HUMAN; MIDDLE-AGED; AGED; AGED-80-AND-OVER; RANDOMIZED-CONTROLLED-TRIAL; CLINICAL-TRIAL; TREATMENT-OUTCOME |
| Further information | Trial information has been obtained from the March 2003, 2004, 2005, 2006 and 2007 submissions to the National Research Register (NRR) archived as of Dec 2007. |
| Date refreshed in mRCT | Updated 06 February 2008 |
