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S0325 Imatinib Mesylate or Dasatinib in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia
Link to the ClinicalTrials.gov recordInformation obtained from ClinicalTrials.gov on February 23, 2012
Title of trial/grant titleS0325 Imatinib Mesylate or Dasatinib in Treating Patients With Chronic Phase Chronic Myelogenous Leukemia
Current status of trialActive, not recruiting
Sponsors and collaboratorsSouthwest Oncology Group
National Cancer Institute (NCI)
Eastern Cooperative Oncology Group
Information provided bySouthwest Oncology Group
ClinicalTrials.gov identifierNCT00070499
PurposeRATIONALE: Imatinib mesylate or dasatinib may stop the growth of cancer cells by blocking
the enzymes necessary for cancer cell growth.

PURPOSE: This randomized phase II trial is studying imatinib mesylate at two different doses
and dasatinib to see how well they work in treating patients with previously untreated
chronic phase chronic myelogenous leukemia.
Condition(s)Leukemia
Intervention(s)Drug: dasatinib
Drug: imatinib mesylate
PhasePhase II
Study type and designAllocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Official titleA Phase IIb Study Of Molecular Responses To Imatinib At Standard Or Increased Doses or Dasatinib (NSC-732517) For Previously Untreated Patients With Chronic Myelogenous Leukemia (CML) In Chronic Phase
Further study detailsOBJECTIVES:

- Compare the rate of molecular response, as measured by the decrease in bcr-abl
transcripts after 12 months of treatment, in patients with previously untreated chronic
phase chronic myelogenous leukemia treated with imatinib mesylate at standard vs
increased dose or dasatinib.

- Test whether increasing doese of imatinib mesylate from 400 mg/day to 800 mg/day
increases molecular response rate (as measured by decrese in bcr-abl transcript after
12 months of treatment) in these patients.

- Compare rates of cytogenetic and hematologic response in patients treated with these
regimens.

- Compare, preliminarily, the prognostic effects of der(9) and der(22) chromosomal
deletions for response in patients treated with these regimens.

- Compare, preliminarily, changes in gene expression at pre-treatment vs at relapse or
progression in patients treated with these regimens.

- Compare the frequency and severity of the toxic effects of these regimens in these
patients.

- Compare, preliminarily, the overall survival and relapse-free survival of patients
treated with these regimens.

OUTLINE: This is a randomized, multicenter study. Patients are stratified according to
Hasford risk category (low vs intermediate vs high). Patients are randomized to 1 of 3
treatment arms.

- Arm I: Patients receive oral imatinib mesylate once daily.

- Arm II: Patients receive oral imatinib mesylate twice daily.

- Arm III: Patients receive oral dasatinib twice daily. In all arms, treatment continues
for 5 years in the absence of disease progression or unacceptable toxicity.

Patients are followed for up to 5 years.

PROJECTED ACCRUAL: A total of 335 patients will be accrued for this study.
Primary outcomeMolecular response at 12 months No
Hematological response No
Cytogenetic response (complete and partial response) measured on bone marrow at baseline, 6 and 12 months No
Prognostic effects No
Changes in gene expression at pre-treatment and relapse No
Frequency and severity of toxic effects Yes
Overall and relapse-free survival No
Study startAugust 2004
Minimum age18 Years
Maximum ageN/A
GenderBoth
Eligibility criteriaDISEASE CHARACTERISTICS:

- Diagnosis of chronic phase chronic myelogenous leukemia (CML) by bone marrow
aspiration, biopsy, and peripheral blood counts, meeting criteria for 1 of the
following:

- Philadelphia chromosome-positive* or presence of the variants of the (9;22)
translocation by cytogenetics or fluorescent in situ hybridization

- Secondary chromosomal abnormalities (in addition to the Philadelphia
chromosome) allowed

- bcr-abl positive* by reverse transcription polymerase chain reaction NOTE:
*First cytogenetic or molecular analysis performed within the past 180 days to
confirm status

- Must be enrolled on SWOG-9007 (SWOG institutions only) and SWOG-S9910

PATIENT CHARACTERISTICS:

Age

- 18 and over

Performance status

- Zubrod 0-2

Life expectancy

- Not specified

Hematopoietic

- No significant bleeding disorder unrelated to cancer including:

- Congenital bleeding disorders (e.g., von Willebrand's disease)

- Acquired bleeding disorder within the past year (e.g., acquired anti-factor VIII
antibodies)

Hepatic

- Bilirubin no greater than 2.0 times upper limit of normal (ULN)

- AST or ALT no greater than 2.0 times ULN

Renal

- Not specified

Cardiovascular

- No cardiac symptoms including any of the following:

- Uncontrolled angina

- Congestive heart failure or myocardial infarction within the past 6 months

- Diagnosed or suspected congenital long QT syndrome

- History of clinically significant ventricular arrhythmias (e.g., ventricular
tachycardia, ventricular fibrillation, or Torsades de pointes)

- Prolonged QTc interval on electrocardiogram (> 450 msec)

- Uncontrolled hypertension

Other

- Not pregnant or nursing

- Fertile patients must use effective contraception

- No other malignancy within the past 5 years except adequately treated basal cell or
squamous cell skin cancer, carcinoma in situ of the cervix, or adequately treated
stage I or II cancer currently in complete remission

PRIOR CONCURRENT THERAPY:

Biologic therapy

- No other concurrent anticancer biologic agents

Chemotherapy

- No prior chemotherapy for peripheral blood stem cell mobilization

- Prior collection of unmobilized peripheral blood stem cells allowed

- No other concurrent anticancer chemotherapy

- Concurrent hydroxyurea and/or anagrelide to control blood counts allowed
provided it is only administered during the first 28 days of study therapy and
for no more than 28 additional days after study therapy

Endocrine therapy

- Not specified

Radiotherapy

- No concurrent anticancer radiotherapy

Surgery

- More than 28 days since prior major surgery and recovered

Other

- No prior treatment for CML (except hydroxyurea and/or anagrelide)

- No concurrent therapeutic anticoagulation with warfarin

- Concurrent therapeutic anticoagulation with low-molecular weight heparin allowed

- Concurrent low-dose warfarin for prophylaxis to prevent catheter thrombosis
allowed (arm III only)

- No concurrent drugs* that have a risk of causing Torsades de Pointe including (arm
III patients only):

- Quinidine, procainamide, disopyramide

- Amiodarone, sotalol, ibutilide, dofetilide

- Erythromycin, clarithromycin

- Chlorpromazine, haloperidol, mesoridazine, thioridazine, pimozide

- Cisapride, bepridil, droperidol, methadone, arsenic, chloroquine, domperidone

- Halofantrine, levomethadyl, pentamidine, sparfloxacin, lidoflazine NOTE:
*Patients who have discontinued any of these medications must have a wash-out
period of at least 5 days or at least 5 half-lives of the drug prior to first
dose of dasatinib

- No concurrent drugs that irreversibly inhibit platelet function, including any of the
following (arm III only):

- Aspirin

- Patients who have discontinued aspirin must have a wash-out period of at
least 7 days for low-dose aspirin (< 325 mg/day) or 14 days for high-dose
aspirin (> 325 mg/day) prior to first dose of dasatinib

- Dipyridamole

- Epoprostenol

- Eptifibatide

- Clopidogrel

- Cilostazol

- Abciximab

- Ticlopidine

- No other concurrent anticancer agents
Study chairs or principal investigatorsBrian J. Druker, MD, Study Chair, OHSU Knight Cancer Institute
Marilyn L. Slovak, PhD, Principal Investigator, Beckman Research Institute
Peter D. Emanuel, MD, Principal Investigator, University of Alabama at Birmingham
LocationsCalifornia, United States

Providence Saint Joseph Medical Center - Burbank
Burbank
California
91505

California, United States

USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles
California
90089-9181

Delaware, United States

Tunnell Cancer Center at Beebe Medical Center
Lewes
Delaware
19958

Delaware, United States

CCOP - Christiana Care Health Services
Newark
Delaware
19713

Florida, United States

Mayo Clinic - Jacksonville
Jacksonville
Florida
32224

Florida, United States

University of Miami Sylvester Comprehensive Cancer Center - Miami
Miami
Florida
33136

Florida, United States

M.D. Anderson Cancer Center at Orlando
Orlando
Florida
32806

Illinois, United States

Saint Anthony's Hospital at Saint Anthony's Health Center
Alton
Illinois
62002

Illinois, United States

Rush-Copley Cancer Care Center
Aurora
Illinois
60504

Illinois, United States

St. Joseph Medical Center
Bloomington
Illinois
61701

Illinois, United States

Graham Hospital
Canton
Illinois
61520

Illinois, United States

Memorial Hospital
Carthage
Illinois
62321

Illinois, United States

Veterans Affairs Medical Center - Chicago Westside Hospital
Chicago
Illinois
60612

Illinois, United States

University of Chicago Cancer Research Center
Chicago
Illinois
60637-1470

Illinois, United States

University of Illinois Cancer Center
Chicago
Illinois
60612-7243

Illinois, United States

Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago
Illinois
60611-3013

Illinois, United States

Hematology and Oncology Associates
Chicago
Illinois
60611

Illinois, United States

Decatur Memorial Hospital Cancer Care Institute
Decatur
Illinois
62526

Illinois, United States

Eureka Community Hospital
Eureka
Illinois
61530

Illinois, United States

Galesburg Clinic, PC
Galesburg
Illinois
61401

Illinois, United States

Galesburg Cottage Hospital
Galesburg
Illinois
61401

Illinois, United States

Mason District Hospital
Havana
Illinois
62644

Illinois, United States

Hopedale Medical Complex
Hopedale
Illinois
61747

Illinois, United States

Midwest Center for Hematology/Oncology
Joliet
Illinois
60432

Illinois, United States

Joliet Oncology-Hematology Associates, Limited - West
Joliet
Illinois
60435

Illinois, United States

North Shore Oncology and Hematology Associates, Limited - Libertyville
Libertyville
Illinois
60048

Illinois, United States

McDonough District Hospital
Macomb
Illinois
61455

Illinois, United States

Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood
Illinois
60153

Illinois, United States

Good Samaritan Regional Health Center
Mt. Vernon
Illinois
62864

Illinois, United States

La Grange Oncology Associates - Geneva
Naperville
Illinois
60563

Illinois, United States

Cancer Care and Hematology Specialists of Chicagoland - Niles
Niles
Illinois
60714

Illinois, United States

Community Cancer Center
Normal
Illinois
61761

Illinois, United States

BroMenn Regional Medical Center
Normal
Illinois
61761

Illinois, United States

Community Hospital of Ottawa
Ottawa
Illinois
61350

Illinois, United States

Oncology Hematology Associates of Central Illinois, PC - Ottawa
Ottawa
Illinois
61350

Illinois, United States

Cancer Treatment Center at Pekin Hospital
Pekin
Illinois
61554

Illinois, United States

Oncology Hematology Associates of Central Illinois, PC - Peoria
Peoria
Illinois
61615

Illinois, United States

OSF St. Francis Medical Center
Peoria
Illinois
61637

Illinois, United States

Proctor Hospital
Peoria
Illinois
61614

Illinois, United States

Methodist Medical Center of Illinois
Peoria
Illinois
61636

Illinois, United States

CCOP - Illinois Oncology Research Association
Peoria
Illinois
61615

Illinois, United States

Illinois Valley Community Hospital
Peru
Illinois
61354

Illinois, United States

Perry Memorial Hospital
Princeton
Illinois
61356

Illinois, United States

Swedish-American Regional Cancer Center
Rockford
Illinois
61104-2315

Illinois, United States

Hematology Oncology Associates - Skokie
Skokie
Illinois
60076

Illinois, United States

St. Margaret's Hospital
Spring Valley
Illinois
61362

Illinois, United States

Regional Cancer Center at Memorial Medical Center
Springfield
Illinois
62781-0001

Illinois, United States

CCOP - Carle Cancer Center
Urbana
Illinois
61801

Illinois, United States

Carle Cancer Center at Carle Foundation Hospital
Urbana
Illinois
61801

Indiana, United States

Fort Wayne Medical Oncology and Hematology
Fort Wayne
Indiana
46815

Indiana, United States

Saint Anthony Memorial Health Centers
Michigan City
Indiana
46360

Iowa, United States

McFarland Clinic, PC
Ames
Iowa
50010

Kansas, United States

Cancer Center of Kansas, PA - Chanute
Chanute
Kansas
66720

Kansas, United States

Cancer Center of Kansas, PA - Dodge City
Dodge City
Kansas
67801

Kansas, United States

Cancer Center of Kansas, PA - El Dorado
El Dorado
Kansas
67042

Kansas, United States

Cancer Center of Kansas-Independence
Independence
Kansas
67301

Kansas, United States

Cancer Center of Kansas, PA - Kingman
Kingman
Kansas
67068

Kansas, United States

Lawrence Memorial Hospital
Lawrence
Kansas
66044

Kansas, United States

Southwest Medical Center
Liberal
Kansas
67901

Kansas, United States

Cancer Center of Kansas, PA - Newton
Newton
Kansas
67114

Kansas, United States

Menorah Medical Center
Overland Park
Kansas
66209

Kansas, United States

Cancer Center of Kansas, PA - Parsons
Parsons
Kansas
67357

Kansas, United States

Cancer Center of Kansas, PA - Pratt
Pratt
Kansas
67124

Kansas, United States

Cancer Center of Kansas, PA - Salina
Salina
Kansas
67042

Kansas, United States

Shawnee Mission Medical Center
Shawnee Mission
Kansas
66204

Kansas, United States

Cotton-O'Neil Cancer Center
Topeka
Kansas
66606

Kansas, United States

Cancer Center of Kansas, PA - Wellington
Wellington
Kansas
67152

Kansas, United States

Cancer Center of Kansas, PA - Medical Arts Tower
Wichita
Kansas
67208

Kansas, United States

Cancer Center of Kansas, PA - Wichita
Wichita
Kansas
67214

Kansas, United States

Associates in Womens Health, PA - North Review
Wichita
Kansas
67208

Kansas, United States

CCOP - Wichita
Wichita
Kansas
67214

Kansas, United States

Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita
Kansas
67214

Kansas, United States

Cancer Center of Kansas, PA - Winfield
Winfield
Kansas
67156

Maine, United States

CancerCare of Maine at Eastern Maine Medical Center
Bangor
Maine
04401

Maine, United States

York Hospital's Oncology Treatment Center
York
Maine
03909

Maryland, United States

Union Hospital Cancer Program at Union Hospital
Elkton MD
Maryland
21921

Massachusetts, United States

Dana-Farber/Brigham and Women's Cancer Center
Boston
Massachusetts
02115

Massachusetts, United States

Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute
Boston
Massachusetts
02115

Massachusetts, United States

Massachusetts General Hospital
Boston
Massachusetts
02114

Michigan, United States

CCOP - Michigan Cancer Research Consortium
Ann Arbor
Michigan
48106

Michigan, United States

Saint Joseph Mercy Cancer Center
Ann Arbor
Michigan
48106-0995

Michigan, United States

University of Michigan Comprehensive Cancer Center
Ann Arbor
Michigan
48109-0942

Michigan, United States

Oakwood Cancer Center at Oakwood Hospital and Medical Center
Dearborn
Michigan
48123-2500

Michigan, United States

Genesys Hurley Cancer Institute
Flint
Michigan
48503

Michigan, United States

Hurley Medical Center
Flint
Michigan
48503

Michigan, United States

Van Elslander Cancer Center at St. John Hospital and Medical Center
Grosse Pointe Woods
Michigan
48236

Michigan, United States

Foote Memorial Hospital
Jackson
Michigan
49201

Michigan, United States

West Michigan Cancer Center
Kalamazoo
Michigan
49007-3731

Michigan, United States

Bronson Methodist Hospital
Kalamazoo
Michigan
49007

Michigan, United States

Borgess Medical Center
Kalamazoo
Michigan
49001

Michigan, United States

Sparrow Regional Cancer Center
Lansing
Michigan
48912-1811

Michigan, United States

St. Mary Mercy Hospital
Livonia
Michigan
48154

Michigan, United States

St. Joseph Mercy Oakland
Pontiac
Michigan
48341-2985

Michigan, United States

Mercy Regional Cancer Center at Mercy Hospital
Port Huron
Michigan
48060

Michigan, United States

Seton Cancer Institute at Saint Mary's - Saginaw
Saginaw
Michigan
48601

Michigan, United States

Providence Cancer Institute at Providence Hospital - Southfield Campus
Southfield
Michigan
48075

Michigan, United States

St. John Macomb Hospital
Warren
Michigan
48093

Minnesota, United States

Fairview Ridges Hospital
Burnsville
Minnesota
55337

Minnesota, United States

Mercy and Unity Cancer Center at Mercy Hospital
Coon Rapids
Minnesota
55433

Minnesota, United States

Fairview Southdale Hospital
Edina
Minnesota
55435

Minnesota, United States

Mercy and Unity Cancer Center at Unity Hospital
Fridley
Minnesota
55432

Minnesota, United States

Hutchinson Area Health Care
Hutchinson
Minnesota
55350

Minnesota, United States

Meeker County Memorial Hospital
Lichfield
Minnesota
55355

Minnesota, United States

HealthEast Cancer Care at St. John's Hospital
Maplewood
Minnesota
55109

Minnesota, United States

Minnesota Oncology Hematology, PA - Maplewood
Maplewood
Minnesota
55109

Minnesota, United States

Hennepin County Medical Center - Minneapolis
Minneapolis
Minnesota
55415

Minnesota, United States

Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
Minneapolis
Minnesota
55407

Minnesota, United States

Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
Robbinsdale
Minnesota
55422-2900

Minnesota, United States

Mayo Clinic Cancer Center
Rochester
Minnesota
55905

Minnesota, United States

CCOP - Metro-Minnesota
Saint Louis Park
Minnesota
55416

Minnesota, United States

Park Nicollet Cancer Center
Saint Louis Park
Minnesota
55416

Minnesota, United States

United Hospital
Saint Paul
Minnesota
55102

Minnesota, United States

St. Francis Cancer Center at St. Francis Medical Center
Shakopee
Minnesota
55379

Minnesota, United States

Regions Hospital Cancer Care Center
St. Paul
Minnesota
55101

Minnesota, United States

Ridgeview Medical Center
Waconia
Minnesota
55387

Minnesota, United States

Minnesota Oncology Hematology, PA - Woodbury
Woodbury
Minnesota
55125

Mississippi, United States

Regional Cancer Center at Singing River Hospital
Pascagoula
Mississippi
39581

Missouri, United States

Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
Cape Girardeau
Missouri
63701

Missouri, United States

Saint Francis Medical Center
Cape Girardeau
Missouri
63703

Missouri, United States

Independence Regional Health Center
Independence
Missouri
64050

Missouri, United States

CCOP - Kansas City
Kansas City
Missouri
64131

Missouri, United States

North Kansas City Hospital
Kansas City
Missouri
64116

Missouri, United States

Parvin Radiation Oncology
Kansas City
Missouri
64116

Missouri, United States

Research Medical Center
Kansas City
Missouri
64132

Missouri, United States

Saint Luke's Cancer Institute at Saint Luke's Hospital
Kansas City
Missouri
64111

Missouri, United States

Truman Medical Center - Hospital Hill
Kansas City
Missouri
64108

Missouri, United States

St. Joseph Medical Center
Kansas City
Missouri
64114

Missouri, United States

Heartland Regional Medical Center
Saint Joseph
Missouri
64506

Missouri, United States

Midwest Hematology Oncology Group, Incorporated
Saint Louis
Missouri
63109

Missouri, United States

David C. Pratt Cancer Center at St. John's Mercy
Saint Louis
Missouri
63141

Missouri, United States

Saint Louis University Cancer Center
Saint Louis
Missouri
63110

Missouri, United States

CCOP - St. Louis-Cape Girardeau
Saint Louis
Missouri
63141

Montana, United States

St. Vincent Healthcare Cancer Care Services
Billings
Montana
59101

Montana, United States

Billings Clinic - Downtown
Billings
Montana
59107-7000

Montana, United States

CCOP - Montana Cancer Consortium
Billings
Montana
59101

Montana, United States

Hematology-Oncology Centers of the Northern Rockies - Billings
Billings
Montana
59101

Montana, United States

Northern Rockies Radiation Oncology Center
Billings
Montana
59101

Montana, United States

St. James Healthcare Cancer Care
Butte
Montana
59701

Montana, United States

Big Sky Oncology
Great Falls
Montana
59405-5309

Montana, United States

Great Falls Clinic - Main Facility
Great Falls
Montana
59405

Montana, United States


Great Falls
Montana
59405

Montana, United States

Sletten Cancer Institute at Benefis Healthcare
Great Falls
Montana
59405

Montana, United States

Kalispell Medical Oncology at KRMC
Kalispell
Montana
59901

Montana, United States

Kalispell Regional Medical Center
Kalispell
Montana
59901

Montana, United States

Glacier Oncology, PLLC
Kalispell
Montana
59901

Montana, United States

Montana Cancer Specialists at Montana Cancer Center
Missoula
Montana
59807-7877

Montana, United States

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Missoula
Montana
59807

Montana, United States

Guardian Oncology and Center for Wellness
Missoula
Montana
59804

Montana, United States

Community Medical Center
Missoula
Montana
59801

New Jersey, United States

Cancer Institute of New Jersey at Cooper - Voorhees
Voorhees
New Jersey
08043

New York, United States

Our Lady of Mercy Medical Center Comprehensive Cancer Center
Bronx
New York
10466

New York, United States

Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital
Cooperstown
New York
13326

New York, United States

CCOP - Hematology-Oncology Associates of Central New York
East Syracuse
New York
13057

New York, United States

Adirondack Cancer Care - Glens Falls
Glens Falls
New York
12801

New York, United States

James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester
New York
14642

New York, United States

Interlakes Oncology/Hematology PC
Rochester
New York
14623

New York, United States

SUNY Upstate Medical University Hospital
Syracuse
New York
13210

New York, United States

Veterans Affairs Medical Center - Syracuse
Syracuse
New York
13210

North Carolina, United States

Blumenthal Cancer Center at Carolinas Medical Center
Charlotte
North Carolina
28232-2861

North Carolina, United States

Wayne Memorial Hospital, Incorporated
Goldsboro
North Carolina
27534

North Carolina, United States

Kinston Medical Specialists
Kinston
North Carolina
28501

North Carolina, United States

Rutherford Hospital
Rutherfordton
North Carolina
28139

North Carolina, United States

Iredell Memorial Hospital
Statesville
North Carolina
28677

North Carolina, United States

Wake Forest University Comprehensive Cancer Center
Winston-Salem
North Carolina
27157-1096

Ohio, United States

Mary Rutan Hospital
Bellefontaine
Ohio
43311

Ohio, United States

Aultman Cancer Center at Aultman Hospital
Canton
Ohio
44710-1799

Ohio, United States

Adena Regional Medical Center
Chillicothe
Ohio
45601

Ohio, United States

Charles M. Barrett Cancer Center at University Hospital
Cincinnati
Ohio
45267

Ohio, United States

Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
Columbus
Ohio
43210-1240

Ohio, United States

CCOP - Columbus
Columbus
Ohio
43215

Ohio, United States

Doctors Hospital at Ohio Health
Columbus
Ohio
43228

Ohio, United States

Grant Medical Center Cancer Care
Columbus
Ohio
43215

Ohio, United States

Riverside Methodist Hospital Cancer Care
Columbus
Ohio
43214-3998

Ohio, United States

Mount Carmel Health - West Hospital
Columbus
Ohio
43222

Ohio, United States

Grady Memorial Hospital
Delaware
Ohio
43015

Ohio, United States

Fairfield Medical Center
Lancaster
Ohio
43130

Ohio, United States

St. Rita's Medical Center
Lima
Ohio
45801

Ohio, United States

MedCentral - Mansfield Hospital
Mansfield
Ohio
44903

Ohio, United States

Strecker Cancer Center at Marietta Memorial Hospital
Marietta
Ohio
45750

Ohio, United States

Licking Memorial Cancer Care Program at Licking Memorial Hospital
Newark
Ohio
43055

Ohio, United States

Community Hospital of Springfield and Clark County
Springfield
Ohio
45505

Ohio, United States

Mercy Medical Center
Springfield
Ohio
45504

Ohio, United States

Mount Carmel St. Ann's Cancer Center
Westerville
Ohio
43081

Ohio, United States

Genesis - Good Samaritan Hospital
Zanesville
Ohio
43701

Oklahoma, United States

Natalie Warren Bryant Cancer Center at St. Francis Hospital
Tulsa
Oklahoma
74136

Oregon, United States

Kaiser Permanente Health Care - Portland
Portland
Oregon
97232

Pennsylvania, United States

St. Luke's Cancer Network at St. Luke's Hospital
Bethlehem
Pennsylvania
18015

Pennsylvania, United States

Geisinger Cancer Institute at Geisinger Health
Danville
Pennsylvania
17822-0001

Pennsylvania, United States

Penn State Cancer Institute at Milton S. Hershey Medical Center
Hershey
Pennsylvania
17033-0850

Pennsylvania, United States

Lewistown Hospital
Lewistown
Pennsylvania
17044

Pennsylvania, United States

Frankford Hospital Cancer Center - Torresdale Campus
Philadelphia
Pennsylvania
19114

Pennsylvania, United States

Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
Pittsburgh
Pennsylvania
15224-1791

Pennsylvania, United States

Mount Nittany Medical Center
State College
Pennsylvania
16803

South Carolina, United States

AnMed Cancer Center
Anderson
South Carolina
29621

South Carolina, United States

McLeod Regional Medical Center
Florence
South Carolina
29501

South Carolina, United States

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
Spartanburg
South Carolina
29303

South Carolina, United States

CCOP - Upstate Carolina
Spartanburg
South Carolina
29303

South Dakota, United States

Medical X-Ray Center, PC
Sioux Falls
South Dakota
57105

South Dakota, United States

Avera Cancer Institute
Sioux Falls
South Dakota
57105

South Dakota, United States

Sanford Cancer Center at Sanford USD Medical Center
Sioux Falls
South Dakota
57117-5039

Texas, United States

Cancer Therapy and Research Center
San Antonio
Texas
78229

Texas, United States

University Hospital - San Antonio
San Antonio
Texas
78229

Texas, United States

University of Texas Health Science Center at San Antonio
San Antonio
Texas
78229-3900

Texas, United States

Veterans Affairs Medical Center - San Antonio (Murphy)
San Antonio
Texas
78209

Utah, United States

Huntsman Cancer Institute at University of Utah
Salt Lake City
Utah
84112

Washington, United States

St. Joseph Cancer Center
Bellingham
Washington
98225

Washington, United States

Olympic Hematology and Oncology
Bremerton
Washington
98310

Washington, United States

Columbia Basin Hematology
Kennewick
Washington
99336

Washington, United States

Group Health Central Hospital
Seattle
Washington
98112

Washington, United States

Harborview Medical Center
Seattle
Washington
98104

Washington, United States

Minor and James Medical, PLLC
Seattle
Washington
98104

Washington, United States

Polyclinic First Hill
Seattle
Washington
98122

Washington, United States

Fred Hutchinson Cancer Research Center
Seattle
Washington
98104

Washington, United States

University Cancer Center at University of Washington Medical Center
Seattle
Washington
98195-6043

Washington, United States

Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Seattle
Washington
98122-4307

Washington, United States

Cancer Care Northwest - Spokane South
Spokane
Washington
99202

Wisconsin, United States

Marshfield Clinic Cancer Care at Regional Cancer Center
Eau Claire
Wisconsin
54701

Wisconsin, United States

Center for Cancer Treatment & Prevention at Sacred Heart Hospital
Eau Claire
Wisconsin
54701

Wisconsin, United States

Gundersen Lutheran Center for Cancer and Blood
La Crosse
Wisconsin
54601

Wisconsin, United States

Saint Joseph's Hospital
Marshfield
Wisconsin
54449

Wisconsin, United States

Marshfield Clinic - Marshfield Center
Marshfield
Wisconsin
54449

Wisconsin, United States

Medical College of Wisconsin Cancer Center
Milwaukee
Wisconsin
53226

Wisconsin, United States

Froedtert Hospital and Medical College of Wisconsin
Milwaukee
Wisconsin
53226

Wisconsin, United States

Marshfield Clinic - Lakeland Center
Minocqua
Wisconsin
54548

Wisconsin, United States

Ministry Medical Group at Saint Mary's Hospital
Rhinelander
Wisconsin
54501

Wisconsin, United States

Marshfield Clinic - Indianhead Center
Rice Lake
Wisconsin
54868

Wisconsin, United States

Saint Michael's Hospital Cancer Center
Stevens Point
Wisconsin
54481

Wisconsin, United States

Marshfield Clinic - Wausau Center
Wausau
Wisconsin
54401

Wisconsin, United States

Marshfield Clinic - Weston Center
Weston
Wisconsin
54476

Wisconsin, United States

Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids
Wisconsin
54494
LinksClinical trial summary from the National Cancer Institute's PDQ® database
Featured trial article
Study ID numbersCDR0000334588; U10CA032102; S0325; S0325
Last updatedJuly 19, 2011
Record first receivedOctober 3, 2003
ClinicalTrials.gov identifierNCT00070499
Download dateInformation obtained from ClinicalTrials.gov on February 23, 2012
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