| Source of record | UK Trials |
| ISRCTN | ISRCTN57454527 |
| Date ISRCTN assigned | 11/10/2004 |
| Local reference number(s) | N/A |
| Public title | The second multi-centre intra-pleural sepsis trial (MIST2), to assess whether DNase or Alteplase, improve pleural fluid drainage in pleural infection |
| Scientific title |
|
| Acronym | Multi-centre Intra-pleural Sepsis Trial (MIST2) |
| Disease/condition/study domain | Pleural infection |
| Study hypothesis | Not provided at time of registration.
|
| Design/methodology | Randomised controlled trial |
| Research ethics review | Not provided at time of registration.
|
| Countries of trial | United Kingdom |
| Participants - inclusion criteria | Patients with a clinical presentation compatible with pleural infection, have pleural fluid requiring drainage which is either purulent or gram stain positive or culture positive or is acidic with a pH of <7.2. |
| Participants - exclusion criteria | Not provided at time of registration.
|
| Patient information material |
|
| Anticipated start date | 11/10/2003 |
| Anticipated end date | 11/10/2007 |
| Status of trial | Completed |
| Target number of participants | Added as of 10/09/2007: 210 |
| Interventions | Patients will be randomly assigned in the ratio 1:1:1:1 to either of the following regimes:
Alteplase 10 mg bd (twice a day) intrapleurally + DNase 5 mg bd intrapleurallly; or
Alteplase placebo intrapleurally + DNase 5 mg bd intrapleurally; or
Alteplase 10 mg bd intrapleurally + DNase placebo intrapleurally; or
Alteplase placebo intrapleurally + DNase placebo intrapleurally. |
| Primary outcome measure(s) | Not provided at time of registration.
|
| Secondary outcome measure(s) | Not provided at time of registration.
|
| Trial website | http://www.ctu.mrc.ac.uk/studies/mist2.asp |
| Sources of funding | Unrestricted educational grant from Roche UK |
| Sponsor name | Oxford Radcliffe Hospitals NHS Trust (UK) |
| Sponsor details | R&D Office
Manor House
The John Radcliffe Hospital
Headley Way
Headington
Oxford
United Kingdom
OX3 9DU |
| Contact name | Dr Robert Davies |
| Contact details | Oxford Centre for Respiratory Medicine
Churchill Hospital
Old Road
Headington
Oxford
United Kingdom
OX3 7LJ |
| More information | For more up-to-date information please go to the ISRCTN link below. |
| Link to record in ISRCTN Register | ISRCTN57454527 |
| Date last extracted from ISRCTN register | 17/04/2008 |
