| Source of record | UK Trials |
| ISRCTN | ISRCTN23090699 |
| Date ISRCTN assigned | 12/09/2002 |
| Local reference number(s) | 226/657 |
| Public title | Thyroid dysfunction in the elderly: quantifying the association between sub-clinical disease and (i) atrial fibrillation (and thus stroke) (ii) depression and (iii) cognitive dysfunction. A community based survey and clinical trial of thyroxine therapy |
| Scientific title |
|
| Acronym | BETS (Birmingham Elderly Thyroid Study) |
| Disease/condition/study domain | Thyroid dysfunction |
| Study hypothesis | Not provided at time of registration |
| Design/methodology | Community based survey and randomised controlled trial |
| Research ethics review | Not provided at time of registration |
| Countries of trial | United Kingdom |
| Participants - inclusion criteria | Phase 1: Aged 65+
Phase 2a: Patients identified in Phase 1 to be suffering from sub-clinical hyperthyroidism
Phase 2b: Patients identified in Phase 1 to be suffering from sub-clinical hypothyroidism |
| Participants - exclusion criteria | Not provided at time of registration |
| Patient information material |
|
| Anticipated start date | 01/01/2005 |
| Anticipated end date | 01/01/2006 |
| Status of trial | Completed |
| Target number of participants | Not provided at time of registration |
| Interventions | Intervention: Thyroxine replacement therapy. Dose to be increased by 25 mcg steps during 6 monthly period of monthly monitoring of thyroid function
Control: As for intervention group but placebo |
| Primary outcome measure(s) | Not provided at time of registration |
| Secondary outcome measure(s) | Not provided at time of registration |
| Publications | Results for community based survey: http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17003083 |
| Sources of funding | The Health Foundation (UK) |
| Sponsor name | The Health Foundation (UK) |
| Sponsor details | 90 Long Acre
London
United Kingdom
WC2E 9RA |
| Sponsor telephone | +44 (0)20 7257 8000 |
| Sponsor fax | +44 (0)20 7257 8001 |
| Sponsor email | info@health.org.uk |
| Sponsor website | http://www.pppfoundation.org.uk/ |
| Contact name | Professor James V Parle |
| Contact details | Department of Primary Care and General Practice
University of Birmingham
Edgbaston
United Kingdom
B15 2TT |
| Contact telephone | +44 (0)121 414 6420 |
| Contact fax | +44 (0)121 414 7938 |
| Contact email | j.v.parle@bham.ac.uk |
| More information | For more up-to-date information please go to the ISRCTN link below. |
| Link to record in ISRCTN Register | ISRCTN23090699 |
| Date last extracted from ISRCTN register | 17/04/2008 |
