| Source of record | UK Trials |
| ISRCTN | ISRCTN14031168 |
| Date ISRCTN assigned | 18/11/2001 |
| Local reference number(s) | RG/97010 |
| Public title | HYpertension in the Very Elderly Trial |
| Scientific title |
|
| Acronym | HYVET |
| Disease/condition/study domain | Hypertension |
| Study hypothesis | To assess the benefits of treating very elderly patients with hypertension. |
| Design/methodology | Randomised controlled trial |
| Research ethics review | Not provided at time of registration. |
| Countries of trial | United Kingdom |
| Participants - inclusion criteria | 1. People 80 years old and above
2. Sustained systolic pressure 160 - 199 mmHg and diastolic (phase V) pressure 90 - 109 mmHg
3. No evidence of renal failure or co-morbidity requiring anti-hypertensive treatment |
| Participants - exclusion criteria | Does not comply with above inclusion criteria. |
| Patient information material |
|
| Anticipated start date | 01/01/2001 |
| Anticipated end date | 31/12/2009 |
| Status of trial | Ongoing |
| Target number of participants | 2100 |
| Interventions | Two treatment groups:
1. Placebo
2. Indapamide Sustained Release (SR) 1.5 mg plus perindopril 2 - 4 mg if required.
Goal: diastolic blood pressure less than 80 mmHg with systolic pressure less than 150 mmHg.
The patients are followed-up both according to clinical need and every 3 months in the first year and every 6 months thereafter. |
| Primary outcome measure(s) | Stroke events (fatal and non-fatal). |
| Secondary outcome measure(s) | 1. Total mortality
2. Cardiovascular mortality
3. Cardiac mortality
4. Stroke mortality
5. Skeletal fracture |
| Publications | 1. Main trial protocol in http://www.ncbi.nlm.nih.gov/pubmed/11302283
2. Sub-study protocol in http://www.ncbi.nlm.nih.gov/pubmed/17177983 |
| Sources of funding | 1. British Heart Foundation (UK) (ref: RG/97010)
2. Institut de Recherches Internationales Servier (France) |
| Sponsor name | British Heart Foundation (UK) |
| Sponsor details | 14 Fitzhardinge Street
London
United Kingdom
W1H 6DH |
| Sponsor telephone | +44 (0)20 7935 0185 |
| Sponsor fax | +44 (0)20 7486 5820 |
| Sponsor email | research@bhf.org.uk |
| Sponsor website | http://www.bhf.org.uk/ |
| Contact name | Professor CJ Bulpitt |
| Contact details | Care of the Elderly
Division of Medicine
ICSM at Hammersmith Hospital
Du Cane Road
London
United Kingdom
W12 0NN |
| Contact telephone | +44 (0)20 8383 3959 |
| Contact fax | +44 (0)20 8743 0798 |
| Contact email | c.bulpitt@ic.ac.uk |
| More information | For more up-to-date information please go to the ISRCTN link below. |
| Link to record in ISRCTN Register | ISRCTN14031168 |
| Date last extracted from ISRCTN register | 17/04/2008 |
