| Source of record | UK Trials |
| ISRCTN | ISRCTN31931021 |
| Date ISRCTN assigned | 16/11/2001 |
| Local reference number(s) | RG/98005 |
| Public title | Rescue angioplasty versus conservative treatment or repeat thrombolysis (the REACT trial) |
| Scientific title |
|
| Acronym | REACT |
| Disease/condition/study domain | Myocardial infarction |
| Study hypothesis | Not provided at time of registration |
| Design/methodology | Randomised controlled trial |
| Research ethics review | Not provided at time of registration |
| Countries of trial | United Kingdom |
| Participants - inclusion criteria | 1. Patients with acute myocardial infarction presenting within 6 hours who have received aspirin and an accepted thrombolytic drug
2. Aged 21 - 85 years and able to give informed consent
3. Ability to undertake coronary intervention within 12 hours of onset of chest pain
4. All patients to have failed reperfusion 90 minutes from the start of thrombolysis |
| Participants - exclusion criteria | Not provided at time of registration |
| Patient information material |
|
| Anticipated start date | 01/12/1999 |
| Anticipated end date | 01/03/2004 |
| Status of trial | Stopped |
| Target number of participants | Not provided at time of registration |
| Interventions | Patients to be randomised to:
1. Rescue Percutaneous Transluminal Coronary Angioplasty (PTCA) - stent placement or platelet glycoprotein receptor blockers and the use of intra-aortic balloon pulsation will be guided by clinical need
2. Rescue thrombolysis with tissue Plasminogen Activator (tPA), reteplase, tenecteplase
3. Conservative treatment - intravenous (iv) heparin for 24 hours |
| Primary outcome measure(s) | Not provided at time of registration |
| Secondary outcome measure(s) | Not provided at time of registration |
| Publications | Results in http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=PubMed&list_uids=16382062 |
| Sources of funding | British Heart Foundation (UK) (ref: RG/98005) |
| Sponsor name | British Heart Foundation (UK) |
| Sponsor details | 14 Fitzhardinge Street
London
United Kingdom
W1H 6DH |
| Sponsor telephone | +44 (0)20 7935 0185 |
| Sponsor fax | +44 (0)20 7486 5820 |
| Sponsor email | research@bhf.org.uk |
| Sponsor website | http://www.bhf.org.uk/ |
| Contact name | Dr AH Gershlick |
| Contact details | Academic Dept of Cardiology
Clinical Sciences Wing
Glenfield General Hospital
Leicester
United Kingdom
LE3 9QP |
| Contact telephone | +44 (0)116 256 3038 |
| Contact fax | +44 (0)116 2875792 |
| Contact email | agershlick@aol.com |
| More information | For more up-to-date information please go to the ISRCTN link below. |
| Link to record in ISRCTN Register | ISRCTN31931021 |
| Date last extracted from ISRCTN register | 17/04/2008 |
