| Source of record | UK Trials |
| ISRCTN | ISRCTN24219839 |
| Date ISRCTN assigned | 01/07/2001 |
| Local reference number(s) | LY3 |
| Public title | Trial of PACEBOM versus CHOP in histologically aggressive non-Hodgkins lymphoma |
| Scientific title |
|
| Acronym | N/A |
| Disease/condition/study domain | Lymphoma (non-Hodgkins) |
| Study hypothesis | Not provided at time of registration |
| Design/methodology | Randomised controlled trial |
| Research ethics review | Not provided at time of registration |
| Countries of trial | United Kingdom |
| Participants - inclusion criteria | 1. Aged 16 to 69 years
2. Previously untreated histologically aggressive lymphoma with a large cell component: Diffuse large cell, Diffuse immunoblastic, Diffuse mixed cell
3. Stages II-IV
4. No contraindications to treatment protocols |
| Participants - exclusion criteria | Patients with Burkitt's and lymphoblastic lymphoma to be excluded
|
| Patient information material |
|
| Anticipated start date | 01/11/1987 |
| Anticipated end date | 31/10/1992 |
| Status of trial | Completed |
| Target number of participants | Not provided at time of registration |
| Interventions | Patients were randomised to one of two regimens:
1. CHOP Regimen: Multi-drug chemotherapy with cyclophosphamide, hydroxydaunorubicin, vincristine and prednisolone (CHOP) repeated every 28 days. A minimum of six courses to be given with two courses beyond the attainment of complete response
2. PACEBOM Regimen: Multi-drug chemotherapy with prednisolone, adriamycin, cyclophosphamide and etoposide (PACE) alternating every 7 days with bleomycin, vincristine and methotrexate (BOM). Six cycles of PACE and five of BOM to be given |
| Primary outcome measure(s) | Not provided at time of registration |
| Secondary outcome measure(s) | Not provided at time of registration |
| Publications | 1996 results in http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8688344 |
| Sources of funding | 1. Cancer Research UK
2. Lymphoma Research Trust
3. Lisa Lear Fund
4. Isle of Man Anti-Cancer Association |
| Sponsor name | Cancer Research UK |
| Sponsor details | PO Box 123
Lincoln's Inn Fields
London
United Kingdom
WC2A 3PX |
| Sponsor telephone | +44 (0)20 7317 5186 |
| Sponsor fax | +44 (0)20 7487 4302 |
| Sponsor email | kate.law@cancer.org.uk |
| Sponsor website | http://www.cancer.org.uk |
| Contact name | Dr - - |
| Contact details | UKCCCR Register Co-ordinator
MRC Clinical Trials Unit
222 Euston Road
London
United Kingdom
NW1 2DA |
| More information | For more up-to-date information please go to the ISRCTN link below. |
| Link to record in ISRCTN Register | ISRCTN24219839 |
| Date last extracted from ISRCTN register | 17/04/2008 |
