| Source of record | UK Trials |
| ISRCTN | ISRCTN23196537 |
| Date ISRCTN assigned | 01/07/2001 |
| Local reference number(s) | B29(Scot) |
| Public title | A randomised placebo-controlled trial of epirubicin and quinidine in patients with advanced breast cancer |
| Scientific title |
|
| Acronym | N/A |
| Disease/condition/study domain | Breast |
| Study hypothesis | Not provided at time of registration |
| Design/methodology | Randomised placebo controlled trial |
| Research ethics review | Not provided at time of registration |
| Countries of trial | United Kingdom |
| Participants - inclusion criteria | 1. Histologically proven metastatic or locally advanced disease
2. Measurable or evaluable disease
3. World Health Organisation (WHO) Performance status at least 2
4. Haemoglobin ≥10 g%
5. White Blood Count (WBC) >4.0 x10^9/l
6. Platelets ≥100 x 10^9/l
7. Bilirubin within normal range
8. Not currently receiving hormone treatment
9. No prior chemotherapy for advanced disease |
| Participants - exclusion criteria | Not provided at time of registration |
| Patient information material |
|
| Anticipated start date | 01/01/1988 |
| Anticipated end date | 01/09/1992 |
| Status of trial | Completed |
| Target number of participants | Not provided at time of registration |
| Interventions | Both arms receive Epirubicin 100 mg/m^2 iv every 3 weeks for a maximum of eight doses. At each cycle patients also receive a 6-day course of capsules either Quinidine 250 mg or placebo. |
| Primary outcome measure(s) | Not provided at time of registration |
| Secondary outcome measure(s) | Not provided at time of registration |
| Sources of funding | Cancer Research UK |
| Sponsor name | Cancer Research UK |
| Sponsor details | PO Box 123
Lincoln's Inn Fields
London
United Kingdom
WC2A 3PX |
| Sponsor telephone | +44 (0)20 7317 5186 |
| Sponsor fax | +44 (0)20 7487 4302 |
| Sponsor email | kate.law@cancer.org.uk |
| Sponsor website | http://www.cancer.org.uk |
| Contact name | Dr - - |
| Contact details | UKCCCR Register Co-ordinator
MRC Clinical Trials Unit
222 Euston Road
London
United Kingdom
NW1 2DA |
| Contact telephone | +44 (0) 20 7670 4723 |
| Contact fax | +44 (0) 20 7670 4818 |
| Contact email | register@ctu.mrc.ac.uk |
| More information | For more up-to-date information please go to the ISRCTN link below. |
| Link to record in ISRCTN Register | ISRCTN23196537 |
| Date last extracted from ISRCTN register | 17/04/2008 |
