| Source of record | UK Trials |
| ISRCTN | ISRCTN48374927 |
| Date ISRCTN assigned | 01/03/2001 |
| Local reference number(s) | SP3481 |
| Public title | The role of glutamate in the development of phantom limb pain |
| Scientific title |
|
| Acronym | N/A |
| Disease/condition/study domain | Pain |
| Study hypothesis | Not provided at time of registration |
| Design/methodology | Randomised controlled trial |
| Research ethics review | Not provided at time of registration |
| Countries of trial | United Kingdom |
| Participants - inclusion criteria | 1. Patients undergoing lower limb amputation for peripheral vascular disease or as a result of complications of diabetes mellitus
2. Able to give informed consent and cooperate with pain assessment |
| Participants - exclusion criteria | Not provided at time of registration |
| Patient information material |
|
| Anticipated start date | 01/01/2001 |
| Anticipated end date | 01/01/2007 |
| Status of trial | Completed |
| Target number of participants | Not provided at time of registration |
| Interventions | All patients will have spinal and epidural anaesthesia with bupivacaine established before amputation and will receive an epidural infusion of bupivacaine for 48 to 72 hours after surgery for postoperative analgesia.
Patients will be randomised to receive either:
1. An epidural bolus of ketamine before surgery followed by epidural ketamine infusion for 48 to 72 hours
2. A placebo |
| Primary outcome measure(s) | Not provided at time of registration |
| Secondary outcome measure(s) | Not provided at time of registration |
| Publications | Results in http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17583431 |
| Sources of funding | Action Medical Research (UK) |
| Sponsor name | Action Medical Research (UK) |
| Sponsor details | Vincent House
Horsham West Sussex
United Kingdom
RH12 2DP |
| Contact name | Dr Alastair F Nimmo |
| Contact details | University of Edinburgh Department of Anaesthesia Critical Care and Pain Medicine
Royal Infirmary of Edinburgh
Lauriston Place
Edinburgh
United Kingdom
EH3 9YW |
| Contact telephone | +44 (0)131 536 3652 |
| Contact fax | +44 (0)131 536 3672 |
| Contact email | a.nimmo@ed.ac.uk |
| More information | For more up-to-date information please go to the ISRCTN link below. |
| Link to record in ISRCTN Register | ISRCTN48374927 |
| Date last extracted from ISRCTN register | 17/04/2008 |
