| Source of record | UK Trials |
| ISRCTN | ISRCTN24647151 |
| Date ISRCTN assigned | 06/04/2000 |
| Local reference number(s) | G9000793 |
| Public title | UKCCCR trial to study the effect on breast cancer mortality of annual mammographic screening starting at age 40 |
| Scientific title |
|
| Acronym | The 'Age' trial |
| Disease/condition/study domain | Breast cancer |
| Study hypothesis | To determine the effectiveness of mammographic screening starting at age 40, compared with starting at age 50, in reducing mortality from breast cancer. |
| Design/methodology | Randomised controlled trial |
| Research ethics review | Not provided at time of registration |
| Countries of trial | United Kingdom |
| Participants - inclusion criteria | Women aged 40-41 identified from HA registers |
| Participants - exclusion criteria | Women under care for breast cancer may be removed from the prior notification list by the GPs prior to randomisation |
| Patient information material |
|
| Anticipated start date | 30/07/1990 |
| Anticipated end date | 31/12/2010 |
| Status of trial | Ongoing |
| Target number of participants | 160,000 |
| Interventions | Women in the intervention group are offered annual screening by mammography until the year of their 48th birthday. Screening is by 2-view mammography at 1st screen and single view subsequently. All women in both intervention and control groups will be invited for screening in the NHSBSP between the age of 50-52. |
| Primary outcome measure(s) | Deaths from breast cancer in women free of the disease at trial entry in the two groups. Information on prognostic factors of all breast cancers is also collected. |
| Secondary outcome measure(s) | Not provided at time of registration |
| Publications | Results: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17161727
Protocol: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids= 10572845
Results: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids= 11979379 |
| Sources of funding | Medical Research Council (UK) |
| Sponsor name | Medical Research Council (UK) |
| Sponsor details | 20 Park Crescent
London
United Kingdom
W1B 1AL |
| Sponsor telephone | +44 (0)20 7636 5422 |
| Sponsor fax | +44 (0)20 7436 6179 |
| Sponsor email | clinical.trial@headoffice.mrc.ac.uk |
| Sponsor website | http://www.mrc.ac.uk |
| Contact name | Dr SM Moss |
| Contact details | Cancer Screening Evaluation Unit
Institute of Cancer Research
Section of Epidemiology
D Block Cotswold Road
Sutton Surrey
United Kingdom
SM2 5NG |
| More information | For more up-to-date information please go to the ISRCTN link below. |
| Link to record in ISRCTN Register | ISRCTN24647151 |
| Date last extracted from ISRCTN register | 17/04/2008 |
