| Source of record | UK Trials |
| ISRCTN | ISRCTN95257778 |
| Date ISRCTN assigned | 06/04/2000 |
| Local reference number(s) | G8223452 |
| Public title | UKALL R2 - Acute Lymphoblastic Leukaemia trial |
| Scientific title |
|
| Acronym | UKALL R2 |
| Disease/condition/study domain | Acute Lymphoblastic Leukaemia |
| Study hypothesis | To compare continuing chemotherapy with unrelated donor BMT in relapsed childhood ALL following a common re-induction and consolidation regimen. |
| Design/methodology | Randomised controlled trial |
| Research ethics review | Not provided at time of registration |
| Countries of trial | United Kingdom |
| Participants - inclusion criteria | They are children under 15 years at original diagnosis and treated on UKALL trials or pilot studies with first relapse less than 4 years from the start of treatment of ALL at any site and no suitable related bone marrow treatment (BMT) donor is available |
| Participants - exclusion criteria | 1. They are multiply relapsed patients
2. They have a prior history of toxicity or organ damage such that completion of the protocol is felt unlikely at the outset
3. They have had an isolated CNS or testicular relapse more than 6 months off treatment. |
| Patient information material |
|
| Anticipated start date | 01/02/1995 |
| Anticipated end date | 30/09/2008 |
| Status of trial | Ongoing |
| Target number of participants | 200 - Closed to recruitment - in long term follow-up |
| Interventions | Continuing chemotherapy/unrelated donor BMT |
| Primary outcome measure(s) | Survival, disease free survival |
| Secondary outcome measure(s) | Not provided at time of registration |
| Publications | Results on http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15982346 |
| Sources of funding | UK Medical Research Council |
| Sponsor name | Medical Research Council (UK) |
| Sponsor details | 20 Park Crescent
London
United Kingdom
W1B 1AL |
| Sponsor telephone | +44 (0)20 7636 5422 |
| Sponsor fax | +44 (0)20 7436 6179 |
| Sponsor email | clinical.trial@headoffice.mrc.ac.uk |
| Sponsor website | http://www.mrc.ac.uk |
| Contact name | Dr PJ Darbyshire |
| Contact details | The Children's Hospital
Ladywood Middleway
Birmingham
United Kingdom
B16 8ET |
| More information | For more up-to-date information please go to the ISRCTN link below. |
| Link to record in ISRCTN Register | ISRCTN95257778 |
| Date last extracted from ISRCTN register | 17/04/2008 |
