| Source of record | UK Trials |
| ISRCTN | ISRCTN47862456 |
| Date ISRCTN assigned | 06/04/2000 |
| Local reference number(s) | LU21 |
| Public title | Randomised trial of ifosfamide, carboplatin and etoposide with mid-cycle vincristine (VICE) versus standard practice chemotherapy in patients with limited small cell lung cancer (SCLC) and good performance status |
| Scientific title |
|
| Acronym | N/A |
| Disease/condition/study domain | Cancer |
| Study hypothesis | To compare an intensive regimen of VICE without dose reduction but with dose delay permitted versus standard practice chemotherapy in patients with limited stage SCLC and good performance status |
| Design/methodology | Randomised controlled trial |
| Research ethics review | Not provided at time of registration |
| Countries of trial | United Kingdom |
| Participants - inclusion criteria | 1. Previously untreated SCLC
2. Limited disease
3. WHO 0-2
4. Normal blood count
5. Glomerular Filtration Rate (GFR) greater than 65 ml/min |
| Participants - exclusion criteria | Not provided at time of registration |
| Patient information material |
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| Anticipated start date | 01/12/1995 |
| Anticipated end date | 01/12/2001 |
| Status of trial | Completed |
| Target number of participants | 400 |
| Interventions | 1. One group receives intensive regimen of VICE without dose reduction but with dose delay permitted
2. The other group receives standard practice chemotherapy |
| Primary outcome measure(s) | Survival time, quality of life |
| Secondary outcome measure(s) | Not provided at time of registration |
| Trial website | http://www.ctu.mrc.ac.uk/studies/LU21.asp |
| Publications | Results on http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16293867 |
| Sources of funding | Medical Research Council (UK) |
| Sponsor name | Medical Research Council (UK) |
| Sponsor details | 20 Park Crescent
London
United Kingdom
W1B 1AL |
| Sponsor telephone | +44 (0)20 7636 5422 |
| Sponsor fax | +44 (0)20 7436 6179 |
| Sponsor email | clinical.trial@headoffice.mrc.ac.uk |
| Sponsor website | http://www.mrc.ac.uk |
| Contact name | Dr Danielle Andrews |
| Contact details | MRC Clinical Trials Unit
222 Euston Road
London
United Kingdom
NW1 2DA |
| More information | For more up-to-date information please go to the ISRCTN link below. |
| Link to record in ISRCTN Register | ISRCTN47862456 |
| Date last extracted from ISRCTN register | 17/04/2008 |
