|
ISRCTN
|
ISRCTN98767960
|
|
DOI
|
10.1186/ISRCTN98767960
|
|
ClinicalTrials.gov identifier
|
|
|
EudraCT number
|
|
|
Public title
|
Multicentre study of early Epilepsy and Single Seizures
|
|
Scientific title
|
|
|
Acronym
|
MESS
|
|
Serial number at source
|
G9125371
|
|
Study hypothesis
|
1. To compare seizure recurrence rates associated with policies of immediate or delayed antiepileptic drug therapy in patients with single seizures and early epilepsy using a pragmatic randomized parallel group design.
2. To identify factors of prognostic importance in the recurrence of seizures in the early course of epilepsy
3. To examine the psychosocial outcome of the two randomized policies
|
|
Lay summary
|
Not provided at time of registration
|
|
Ethics approval
|
Not provided at time of registration
|
|
Study design
|
Multicentre randomised controlled trial
|
|
Countries of recruitment
|
United Kingdom
|
|
Disease/condition/study domain
|
Epilepsy
|
|
Participants - inclusion criteria
|
1. An adequately documented recent history of one or more clinically definite spontaneous unprovoked epileptic seizures
2. Clinician is uncertain whether to treat or not
|
|
Participants - exclusion criteria
|
Not provided at time of registration
|
|
Anticipated start date
|
01/01/1993
|
|
Anticipated end date
|
31/12/2002
|
|
Status of trial
|
Completed |
|
Patient information material
|
|
|
Target number of participants
|
1800
|
|
Interventions
|
Immediate/delayed antiepileptic drug therapy
|
|
Primary outcome measure(s)
|
Time to first seizure, time to remission, patient perceived quality of life
|
|
Secondary outcome measure(s)
|
Not provided at time of registration
|
|
Sources of funding
|
Medical Research Council
|
|
Trial website
|
|
|
Publications
|
1. 2005 results in http://www.ncbi.nlm.nih.gov/pubmed/15950714
2. 2006 results in http://www.ncbi.nlm.nih.gov/pubmed/16545748
3. 2006 results in http://www.ncbi.nlm.nih.gov/pubmed/17130429
4. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/21147743
5. 2012 results in http://www.ncbi.nlm.nih.gov/pubmed/22696580
|
|
Contact name
|
Prof
David
Chadwick
|
|
Address
|
Department of Neurological Science
The Walton Centre
Lower Lane
Fazakerley
|
|
City/town
|
Liverpool
|
|
Zip/Postcode
|
L9 7LJ
|
|
Country
|
United Kingdom
|
|
Tel
|
+44 (0)151 529 5461
|
|
Fax
|
+44 (0)151 529 5466
|
|
Email
|
dwc@liv.ac.uk
|
|
Sponsor
|
Medical Research Council (MRC) (UK)
|
|
Address
|
20 Park Crescent
|
|
City/town
|
London
|
|
Zip/Postcode
|
W1B 1AL
|
|
Country
|
United Kingdom
|
|
Tel
|
+44 (0)20 7636 5422
|
|
Fax
|
+44 (0)20 7436 6179
|
|
Email
|
clinical.trial@headoffice.mrc.ac.uk
|
|
Sponsor website:
|
http://www.mrc.ac.uk
|
|
Date applied
|
23/10/2000
|
|
Last edited
|
23/07/2012
|
|
Date ISRCTN assigned
|
23/10/2000
|
