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Intensive insulin therapy does not alter the inflammatory response in patients undergoing coronary artery bypass graft (CABG): a randomized controlled trial
ISRCTN ISRCTN95608630
DOI 10.1186/ISRCTN95608630
ClinicalTrials.gov identifier
EudraCT number
Public title Intensive insulin therapy does not alter the inflammatory response in patients undergoing coronary artery bypass graft (CABG): a randomized controlled trial
Scientific title
Acronym CH0401
Serial number at source CH0401
Study hypothesis Strict glucose control in critically ill patients alters the cytokine balance towards a more pro-inflammatory state.
Lay summary
Ethics approval Not provided at time of registration
Study design Randomised controlled trial
Countries of recruitment Netherlands
Disease/condition/study domain Coronary artery bypass graft
Participants - inclusion criteria 1. Adults, after uncomplicated CABG
2. Non-diabetics
Participants - exclusion criteria 1. Diabetes
2. Renal failure
3. Use of anti-inflammatory drugs
4. Recent myocardial ischemia
Anticipated start date 01/09/2003
Anticipated end date 01/11/2004
Status of trial Completed
Patient information material
Target number of participants 20
Interventions Strict glucose control (blood glucose between 80-110 mg/dl) versus placebo (blood glucose >200 mg/dl).
Primary outcome measure(s) Cytokine levels
Secondary outcome measure(s) Complement concentration
Sources of funding The Department of Intensive Care, Radboud University Nijmegen Medical Centre
Trial website
Publications Results in: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16356228
Contact name Dr  Cornelia  Hoedemaekers
  Address Geert Grooteplein 10
  City/town Nijmegen
  Zip/Postcode 6500 HB
  Country Netherlands
  Email C.Hoedemaekers@ic.umcn.nl
Sponsor Radboud University Nijmegen Medical Centre (The Netherlands)
  Address Geert Groteplein 10
  City/town Nijmegen
  Zip/Postcode 6500 HB
  Country Netherlands
  Tel +31 (0)24 3617273
  Email H.vanderHoeven@ic.umcn.nl
Date applied 24/08/2005
Last edited 29/11/2007
Date ISRCTN assigned 26/08/2005
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