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ISRCTN
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ISRCTN93793971
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DOI
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10.1186/ISRCTN93793971
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ClinicalTrials.gov identifier
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EudraCT number
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Public title
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MRC Adjuvant Gastric Infusional Chemotherapy Trial
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Scientific title
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Acronym
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MAGIC
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Serial number at source
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ST02
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Study hypothesis
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To investigate whether peri-operative chemotherapy prolongs survival
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Lay summary
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Ethics approval
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Not provided at time of registration
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Study design
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Two armed, randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Gastrointestinal cancer
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Participants - inclusion criteria
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1. Histologically proven adenocarcinoma (Stage II or greater) of the lower third oesophagus or stomach, that is considered to be non-urgently resectable with no evidence of distant metastasis
2. Suitable and fit for cytotoxic chemotherapy
3. WHO performance status of 0 or 1
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Participants - exclusion criteria
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1. Other malignant disease other than non-melanomatous skin cancer or in situ carcinoma of the cervix;
2. previous cytotoxic chemotherapy or radiotherapy
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Anticipated start date
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20/06/1994
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Anticipated end date
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31/12/2001
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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500
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Interventions
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Three cycles of pre- and post-operative ECF (Epirubicin, Cisplatin and 5-Fluorouracil) chemotherapy versus surgery alone.
Follow-up: all patients will be followed 6 monthly to 2 years then annually until death.
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Primary outcome measure(s)
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1. Survival time
2. Disease-free survival
3. Quality of life
4. Tumour response
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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Medical Research Council (UK)
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Trial website
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Publications
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Results on http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=Abstract&list_uids=16822992
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Contact name
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Ms
Monica
Verma
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Address
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MRC Clinical Trials Unit
222 Euston Road
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City/town
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London
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Zip/Postcode
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NW1 2DA
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Country
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United Kingdom
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Email
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Sponsor
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Medical Research Council (MRC) (UK)
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Address
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20 Park Crescent
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City/town
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London
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Zip/Postcode
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W1B 1AL
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Country
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United Kingdom
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Tel
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+44 (0)20 7636 5422
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Fax
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+44 (0)20 7436 6179
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Email
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clinical.trial@headoffice.mrc.ac.uk
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Sponsor website:
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http://www.mrc.ac.uk
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Date applied
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06/04/2000
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Last edited
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14/09/2007
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Date ISRCTN assigned
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06/04/2000
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