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ISRCTN
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ISRCTN92846592
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ClinicalTrials.gov identifier
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Public title
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A comparison of the effects of adrenaline and noradrenaline in critically ill patients
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Scientific title
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Acronym
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The Cat study
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Serial number at source
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N/A
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Study hypothesis
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The aim of the Cat study is to compare the clinical effects of adrenaline and noradrenaline in critically ill patients with circulatory dysfunction or failure. It is a prospective, double blind, randomised trial. Patients will be designated a priori into two groups: circulatory failure due to sepsis syndrome/septic shock and circulatory failure due to non-septic causes (cardiogenic shock, normovolaemic hypotension, augmentation of mean arterial pressure). The null hypothesis assumes no difference in resolution of circulatory failure or all-cause mortality in patients with circulatory failure receiving infusions of either adrenaline or noradrenaline.
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Lay summary
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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Australia
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Disease/condition/study domain
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Circulatory failure in critically ill patients
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Participants - inclusion criteria
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Critically ill patients requiring a catacholamine infusion for cardiovascular support
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Participants - exclusion criteria
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Not provided at time of registration
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Anticipated start date
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01/10/2003
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Anticipated end date
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31/10/2005
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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250
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Interventions
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Patients randomised to receive either adrenaline or noradrenaline
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Primary outcome measure(s)
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Time to resolution of circulatory failure to pre-morbid state from commencement of catecholamine.
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Secondary outcome measure(s)
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ICU length of stay and mortality, hospital mortality and 90-day mortality: degree of organ dysfunction during 28-day period (as determined by SOFA scores): cardiovascular, respiratory, renal, neurological, hepatic; and metabolic function.
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Sources of funding
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Not provided at time of registration
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Trial website
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Publications
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2008 results on http://www.ncbi.nlm.nih.gov/pubmed/18654759
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Contact name
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Dr
John
Myburgh
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Address
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Intensive Care Unit
The St George Hospital
Gray Street
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City/town
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Kogarah, Sydney
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Zip/Postcode
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2217
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Country
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Australia
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Sponsor
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The St George Hospital - Dept of Intensive Care (Australia)
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Address
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Gray Street
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City/town
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Kogarah, Sydney
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Zip/Postcode
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2217
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Country
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Australia
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Date applied
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12/11/2004
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Last edited
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30/10/2008
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Date ISRCTN assigned
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07/03/2005
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