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ISRCTN
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ISRCTN92202008
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ClinicalTrials.gov identifier
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Public title
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Can Repellents Prevent Malaria in Africa?
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Scientific title
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Low cost repellents for use in rural Africa: a short-term efficacy, effectiveness and perceived benefit survey in Kilombero, Tanzania
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Acronym
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CRPMA
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Serial number at source
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NIMR/HQ/R8a/VolIX/780
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Study hypothesis
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As Tanzania progresses towards the goals of the Abuja declaration and insecticide-treated bed nets (ITN) coverage becomes almost universal, there is likely to be a selection pressure on malaria mosquitoes to feed outdoors and earlier in the evening when hosts are available. This coupled with changes in lifestyle such as increased access to electricity so people stay awake later means that the relative exposure of the population to infectious mosquito bites is likely to switch to earlier in the evening. A topical insect repellent containing deet can dramatically reduce malaria in South America and Southern Asia where vectors feed early in the evening. The project aims to measure the impact of such a repellent on clinical episodes of malaria in rural Africa.
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Lay summary
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Ethics approval
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1. Ifakara Health Institute Institutional Review Board approved on the 10th November 2008 (ref: IHRDC/IRB/No. A46)
2. National Institute of Medical Research, Tanzania, approved on the 6th March 2009 (ref: NIMR/HQ/R8a/VolIX/780)
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Study design
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Cluster controlled randomised trial
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Countries of recruitment
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Tanzania
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Disease/condition/study domain
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Malaria
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Participants - inclusion criteria
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Household head over 18 years, either sex
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Participants - exclusion criteria
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Under six months of age
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Anticipated start date
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30/08/2009
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Anticipated end date
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30/07/2010
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Status of trial
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Completed |
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Patient information material
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Not available in web format, please use the contact details below to request a patient information sheet
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Target number of participants
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4819
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Interventions
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Long lasting insecticide treated nets (Olyset) + 15% deet repellent
Long lasting insecticide treated nets (Olyset) + placebo lotion
Total duration of intervention: 44 weeks
Total duration of follow-up: 1 month after the trial ends
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Primary outcome measure(s)
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1. Malaria incidence
2. Clinical episodes of malaria
Data is continually collected on a daily basis through passive case detection at a local clinic throughout the trial.
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Secondary outcome measure(s)
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Malaria prevalence.
Data is continually collected on a daily basis through passive case detection at a local clinic throughout the trial.
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Sources of funding
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Population Services International (PSI) (Tanzania) - Innovations Grant
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Trial website
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Publications
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Contact name
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Dr
Sarah
Moore
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Address
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Disease Control and Vector Biology Unit (DCVBU)
London School of Hygiene and Tropical Medicine
Keppel Street
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City/town
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London
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Zip/Postcode
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WC1E 7HT
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Country
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United Kingdom
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Email
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sarah.moore@lshtm.ac.uk
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Sponsor
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Ifakara Health Institute (Tanzania)
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Address
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Box 53
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City/town
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Ifakara
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Zip/Postcode
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53
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Country
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Tanzania
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Sponsor website:
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http://www.ihi.or.tz/
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Date applied
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29/01/2010
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Last edited
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18/02/2010
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Date ISRCTN assigned
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18/02/2010
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