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Pilot study of Cognitive Behaviour Therapy (CBT) versus usual treatment in those with Antisocial Personality Disorder (ASPD) with aggressive behaviour
ISRCTN ISRCTN89922377
DOI 10.1186/ISRCTN89922377
ClinicalTrials.gov identifier
EudraCT number
Public title Pilot study of Cognitive Behaviour Therapy (CBT) versus usual treatment in those with Antisocial Personality Disorder (ASPD) with aggressive behaviour
Scientific title
Acronym ASCOT
Serial number at source G0400922 ID: 71697
Study hypothesis This pilot study has four specific and related aims.
1. Development of treatment
2. Chart treatment as usual
3. Test out standardised measures and different modes of delivery if levels of literacy are found to be poor
4. Determine a preliminary efficacy estimate for CBT in this group
Lay summary
Ethics approval Added as of 13/08/2007:
1. Ethics Board for lead site: NHS Greater Glasgow Primary Care Trust (Community and Mental Health), approved on 16/05/2005 (ref: 05/S0701/46)

Other sites:
2. St Mary's Research Ethics Committee, approved on 10/06/2005
3. Ealing and West London Mental Health Trust (WLMHT) Local Research Ethics Committee, approved on 17/11/2005
Study design Randomised controlled trial
Countries of recruitment United Kingdom
Disease/condition/study domain Antisocial Personality Disorder
Participants - inclusion criteria 1. A diagnosis of ASPD with aggressive behaviour
2. Aged 18 or above
3. Affirmation of any item on the Amended MacArthur Community Violence Screening Instrument (MCVSI)* interview (*3 months prior to baseline)
Participants - exclusion criteria 1. Those who are currently receiving inpatient treatment for a mental state disorder
2. Those currently receiving a systematic psychological therapy
3. Those who have insufficient knowledge of English to enable them to be assessed adequately and to understand the treatment approach
Anticipated start date 13/09/2005
Anticipated end date 12/09/2007
Status of trial Completed
Patient information material
Target number of participants 56 - closed to recruitment - in follow-up
Interventions Cognitive behaviour therapy versus usual treatment
Primary outcome measure(s) Aggression & offending behaviour
Secondary outcome measure(s) 1. Social functioning
2. Anxiety and depression
3. Anger
4. Cost effectiveness
Sources of funding Medical Research Council (MRC) (UK) (G0400922)
Trial website
Publications 2009 results in http://www.ncbi.nlm.nih.gov/pubmed/18667099
Contact name Prof  Kate  Davidson
  Address Psychological Medicine
Gartnavel Royal Hospital
1055 Great Western Road
  City/town Glasgow
  Zip/Postcode G12 0XH
  Country United Kingdom
  Tel +44 (0)141 211 3908/3900
  Fax +44 (0)141 357 4899
  Email k.davidson@clinmed.gla.ac.uk
Sponsor Greater Glasgow NHS (UK)
  Address Research and Development
Gartnavel Royal Hospital
1055 Great Western Road
  City/town Glasgow
  Zip/Postcode G12 0XH
  Country United Kingdom
Date applied 16/08/2005
Last edited 20/08/2009
Date ISRCTN assigned 07/10/2005
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