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ISRCTN
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ISRCTN88164211
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ClinicalTrials.gov identifier
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Public title
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Pathophysiology of Dupuytren's Contracture
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Scientific title
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Acronym
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Pathophysiology of Dupuytren's Contracture
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Serial number at source
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6585
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Study hypothesis
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Dupuytren's disease is a common inheritable disorder, mainly affecting the hand. The digits develop progressive flexion contractures and hand function is significantly impaired. The current mainstay of treatment is surgical excision of the affected tissues but recurrence following excision is seen in approximately 40% of patients. Replacing the palmar skin with grafts obtained from a non-palmar site on the body virtually abolishes recurrence. Based on this well-established surgical observation, we have developed a novel in vitro model, which replicates these interactions between skin cells and the contractile cells responsible for Dupuytren's disease. We have also identified a molecule (tenascin-C), which may control the signalling between these cell types.
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Lay summary
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Ethics approval
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MREC approved (ref: 06/Q0403/95)
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Study design
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Multicentre non-randomised interventional treatment trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Topic: Generic Health Relevance and Cross Cutting Themes; Subtopic: Generic Health Relevance (all Subtopics); Disease: Surgery
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Participants - inclusion criteria
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Not provided at time of registration
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Participants - exclusion criteria
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Not provided at time of registration
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Anticipated start date
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02/11/2006
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Anticipated end date
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31/07/2011
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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Planned sample size: 90
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Interventions
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Elucidate the exact role of tenascin-C in Dupuytren's disease
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Primary outcome measure(s)
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Develop candidate therapeutic target to provide non-surgical intervention to modulate the disease
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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The Healing Foundation (UK)
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Trial website
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Publications
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Contact name
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Mr
Liaquat
Suleman-Verjee
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Address
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Imperial College London
Kennedy Institute of Rheumatology Division
65 Aspenlea Road
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City/town
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London
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Zip/Postcode
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W6 8LH
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Country
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United Kingdom
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Sponsor
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Royal College of Surgeons of England (UK)
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Address
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35-43 Lincoln's Inn Fields
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City/town
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London
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Zip/Postcode
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WC2A 3PE
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Country
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United Kingdom
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Sponsor website:
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http://www.rcseng.ac.uk/
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Date applied
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11/08/2010
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Last edited
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11/08/2010
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Date ISRCTN assigned
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11/08/2010
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