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Cognitive behaviour therapy for co-morbid obsessive compulsive disorder in autism spectrum disorder
ISRCTN ISRCTN87114880
DOI 10.1186/ISRCTN87114880
ClinicalTrials.gov identifier
EudraCT number
Public title Cognitive behaviour therapy for co-morbid obsessive compulsive disorder in autism spectrum disorder
Scientific title Is cognitive behaviour therapy an effective treatment for obsessive compulsive disorder in people with high functioning autism spectrum disorders?
Acronym N/A
Serial number at source N/A
Study hypothesis That cognitive behaviour therapy (CBT) will prove more effective in ameliorating obsessive compulsive disorder (OCD) symptoms in people with autism spectrum disorder (ASD) than an alternative treatment - stress management.
Lay summary Not provided at time of registration
Ethics approval Ethics approval received from the Joint South London and Maudsley and the Institute of Psychiatry NHS Research Ethics Committee on the 10/08/2006 (ref: 06/Q0706/22)
Study design Randomised controlled trial
Countries of recruitment United Kingdom
Disease/condition/study domain Disabling obsessions and compulsions in autism spectrum disorders
Participants - inclusion criteria 1. Male and female, aged 14 years or older to a maximum of 65 years old
2. Verbal intelligence quotient (IQ) greater than 70
3. Diagnoses of ASD and co-morbid OCD
Participants - exclusion criteria 1. Current acute symptoms of psychosis
2. Uncontrolled seizure disorder or substance misuse disorder
Anticipated start date 01/03/2007
Anticipated end date 01/03/2009
Status of trial Completed
Patient information material Information sheet for young people age 14-16 years, for their parents, and for adult participants all available on request at the contact details below.
Target number of participants 40
Interventions Intervention treatment: CBT for obsessive compulsive disorder (OCD)
Control treatment: Stress management

Both treatments contain a significant psycho-educational component about anxiety. The CBT for OCD treatment comprises cognitive and behavioural treatments for OCD including exposure and response prevention. Those participants allocated to the 'control' treatment will be permitted to crossover.

Average duration of each session is 1 hour. Both treatments comprise up to 20 sessions of individual therapy. There is no minimum number of sessions as participants are free to leave the study at any time they wish. In general, the participants receive 1 session per week of treatment, although some participants have more intensive treatment (2 - 3 sessions per week). Therefore, the total duration of intervention depends on each participant.
Primary outcome measure(s) The following will be assessed at baseline (pre-treatment), end of treatment, 1, 3 and 6 months follow-up:
1. The Dimensional Yale Brown Obsessive Compulsive Scale (D-YBOCS)
2. The Obsessive Compulsive Inventory Revised (OCI-R) or Childrens Obsessive Compulsive Inventory (CH-OCI)
3. Beck Depression and Anxiety Scales or Spence Children's Anxiety Scale
4. Clinical Global Impressions Scale
Secondary outcome measure(s) The following will be assessed at baseline (pre-treatment), end of treatment, 1, 3 and 6 months follow-up:
1. Liebowitz Social Anxiety Scale
2. Family Accommodation Scale
3. Work/School and Social adjustment scale
4. Parental CH-OCI
Sources of funding 1. Kings College London, Institute of Psychiatry (UK)
2. South London and Maudsley NHS Trust (UK)
Trial website
Publications 2013 results in: http://www.ncbi.nlm.nih.gov/pubmed/23389964
Contact name Miss  Ailsa  Russell
  Address Po 77 Institute of Psychiatry
Kings College London
Denmark Hill
  City/town London
  Zip/Postcode SE5 4AF
  Country United Kingdom
  Tel +44 (0)20 7848 0655
  Fax +44 (0)20 7848 5006
  Email a.russell@iop.kcl.ac.uk
Sponsor Kings College London, Institute of Psychiatry (UK)
  Address PO 77
Denmark Hill
London
  City/town London
  Zip/Postcode SE5 4AF
  Country United Kingdom
  Sponsor website: http://www.iop.kcl.ac.uk/
Date applied 06/01/2008
Last edited 18/11/2013
Date ISRCTN assigned 21/04/2008
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