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ISRCTN
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ISRCTN87058979
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ClinicalTrials.gov identifier
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Public title
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A randomised study to compare the effectiveness of hyoscine hydrobromide (Hyoscine) and glycopyrronium (Robinul) in the management of noisy breathing/retained secretions in cancer patients
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Scientific title
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Acronym
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N/A
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Serial number at source
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N0258107515
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Study hypothesis
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1. To compare the effectiveness of both hyoscine hydrobromide and glycopyrronium at relieving retained secretions at the time of death.
2. To test feasibility of the advanced 'consent process'.
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Cancer: Noisy breathing, retained secretions
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Participants - inclusion criteria
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Total number of Royal Marsden Hospital patients 205.
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Participants - exclusion criteria
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Does not match inclusion criteria
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Anticipated start date
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28/02/2002
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Anticipated end date
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28/02/2005
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Status of trial
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Completed
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Patient information material
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Target number of participants
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205
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Interventions
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Randomised test intervention versus standardised intervention, non-blinded (Phase 3).
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Primary outcome measure(s)
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1. Provide an evidence base for common practice.
2. Provide a means of obtaining consent for research in dying patients.
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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The Royal Marsden NHS Foundation Trust (UK) Charitable Funds
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Trial website
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Publications
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Contact name
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Dr
Janet
Hardy
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Address
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Palliative Care Services
The Royal Marsden NHS Trust
Downs Road
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City/town
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Sutton, Surrey
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Zip/Postcode
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SM2 5PT
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Country
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United Kingdom
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Sponsor
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Record provided by the NHS Trusts Clinical Trials Register - Department of Health (UK)
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Address
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The Department of Health
Richmond House
79 Whitehall
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City/town
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London
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Zip/Postcode
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SW1A 2NL
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Country
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United Kingdom
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Tel
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+44 (0)20 7307 2622
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Fax
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+44 (0)20 7307 2623
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Email
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dhmail@doh.gsi.org.uk
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Sponsor website:
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http://www.doh.gov.uk
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Date applied
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12/09/2003
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Last edited
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15/07/2009
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Date ISRCTN assigned
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12/09/2003
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