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ISRCTN
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ISRCTN85194921
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ClinicalTrials.gov identifier
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Public title
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What is the effect of alternative summary statistics for communicating risk reduction on decisions about whether to take statins?
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Scientific title
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Acronym
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HIPPO 2 (Health Information Project, Presentation Online)
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Serial number at source
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N/A
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Study hypothesis
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In terms of congruence between decisions and values:
1. "Relative risk reduction" is inferior to the “absolute” summary statistics
2. "Absolute risk reduction" is superior to other “absolute” summary statistics, and
3. There is no congruence between decisions and values for "event rates"
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Ethics approval
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Ethics approval received from the University at Buffalo (New York, USA), Health Sciences Institutional Review Board, approved on 15 May 2002.
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Study design
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Randomised controlled trial
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Countries of recruitment
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Canada, Norway, United States of America
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Disease/condition/study domain
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Hypercholesterolaemia (hypothetical scenario)
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Participants - inclusion criteria
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1. At least 18 years of age
2. Fluent in English or Norwegian
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Participants - exclusion criteria
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Previous participation in this trial
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Anticipated start date
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01/06/2003
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Anticipated end date
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31/07/2005
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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4,800
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Interventions
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Presentations of summary statistic showing evidence of statins' effectiveness in preventing coronary heart disease over ten years.
The participants viewed one of the following six presentations:
1. Relative risk reduction (RRR)
2. Absolute risk reduction (ARR)
3. Numbers needed to treat (NNT)
4. Event rates (ER)
5. Tablets needed to take (TNT)
6. Whole numbers (WN)
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Primary outcome measure(s)
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Hypothetical treatment decision to take or not to take statins.
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Secondary outcome measure(s)
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Understanding of and satisfaction with information, and preferred summary statistic.
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Sources of funding
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Norwegian Research Council (Norway)
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Trial website
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Publications
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1. 2008 results in http://www.ncbi.nlm.nih.gov/pubmed/19030110
2. 2009 results in http://www.ncbi.nlm.nih.gov/pubmed/19707575
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Contact name
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Ms
Cheryl
Carling
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Address
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PO box 7004
St Olavs Plass
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City/town
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Oslo
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Zip/Postcode
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N-0130
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Country
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Norway
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Tel
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+47 (0)98627327
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Email
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cheryl.carling@kunnskapssenteret.no
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Sponsor
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Norwegian Knowledge Centre for the Health Services (Norway)
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Address
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PO box 7004
St Olavs Plass
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City/town
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Oslo
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Zip/Postcode
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N-0130
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Country
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Norway
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Tel
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+47 (0)23 25 50 00
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Fax
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+47 (0)23 25 50 10
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Email
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post@kunnskapssenteret.no
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Sponsor website:
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http://www.kunnskapssenteret.no/
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Date applied
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09/03/2007
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Last edited
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02/09/2009
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Date ISRCTN assigned
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04/05/2007
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