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ISRCTN
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ISRCTN84400696
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ClinicalTrials.gov identifier
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Public title
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A randomised double-blind prospective study to compare the intubating conditions with remifentanil (4 ug/mkg) and either propofol (2 mg/kg) or etomidate (0.3 mg/kg)
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Scientific title
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Acronym
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N/A
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Serial number at source
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N0084113942
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Study hypothesis
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1. To investigate whether there is a role for etomidate for intubation without muscle relaxants?
2. Is it more stable than propofol?
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Surgery: Intubation
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Participants - inclusion criteria
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40 American Society of Anesthesiologists (ASA) 1 and 2 non-obese (Body Mass Index [BMI] <30) elective surgical patients aged between 18 and 65 years. They must require intubation for their proposed surgery.
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Participants - exclusion criteria
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Not provided at time of registration
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Anticipated start date
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01/08/2002
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Anticipated end date
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01/06/2004
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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40
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Interventions
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1. Remifentanil and etomidate
2. Remifentanil and propofol
Both the patients and the intubating anaesthetist will be blinded to the induction agents administered by a second anaesthetist.
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Primary outcome measure(s)
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The end points are:
1. Intubating conditions
2. Cardiovascular stability
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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The North and South Bank Research and Development Consortium (UK)
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Trial website
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Publications
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Contact name
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Dr
Ian
McNeil
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Address
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Department of Anaesthesia
Hull Royal Infirmary
Anlaby Road
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City/town
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Hull
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Zip/Postcode
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HU3 2 JZ
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Country
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United Kingdom
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Email
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Sponsor
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Record provided by the NHS Trusts Clinical Trials Register - Department of Health (UK)
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Address
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The Department of Health
Richmond House
79 Whitehall
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City/town
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London
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Zip/Postcode
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SW1A 2NL
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Country
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United Kingdom
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Tel
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+44 (0)20 7307 2622
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Fax
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+44 (0)20 7307 2623
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Email
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dhmail@doh.gsi.org.uk
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Sponsor website:
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http://www.doh.gov.uk
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Date applied
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12/09/2003
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Last edited
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21/01/2009
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Date ISRCTN assigned
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12/09/2003
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