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A cluster randomised trial of two intensified tuberculosis case-finding strategies in an urban community severely affected by human immunodeficiency virus
ISRCTN ISRCTN84352452
DOI 10.1186/ISRCTN84352452
ClinicalTrials.gov identifier
EudraCT number
Public title A cluster randomised trial of two intensified tuberculosis case-finding strategies in an urban community severely affected by human immunodeficiency virus
Scientific title
Acronym DETECTB
Serial number at source 074644; LSHTM ITCR BA79
Study hypothesis 1. To compare the cumulative yield and residual burden of two potentially sustainable intensified TB case-finding methods applied for 3 years in a high HIV setting
2. To investigate HIV-specific point prevalence and incidence of active TB disease in an urban community before and after the intervention period (as of 13th February 2007 this hypothesis was changed to 'To investigate the change in point prevalence of culture-positive TB disease in an urban community before and after the intervention period')
Lay summary Not provided at time of registration
Ethics approval Not provided at time of registration
Study design Randomised controlled trial
Countries of recruitment Zimbabwe
Disease/condition/study domain Tuberculosis
Participants - inclusion criteria Site:
1. Study neighbourhoods based on Census Evaluation Units (CEUs) in residential suburbs of South-West and Western Harare
2. Three to four CEUs combined to provide:
a. 2000-3000 adults registered for 2002 Census
b. No flats or Halls of Residence
c. At least 500 km distance between study neighbourhoods

All eligible neighbourhoods included
Participants - exclusion criteria Individual:
1. Declined consent to participate
2. Aged below 16 years
Anticipated start date 01/02/2006
Anticipated end date 01/12/2008
Status of trial Completed
Patient information material
Target number of participants 120,000 - 110,000 as of 07/08/2006 (end of recruitment). Follow up continuing.
Interventions Cluster-randomised trial of high density neighbourhoods in Zimbabwe
Randomisation unit: each neighbourhood site
Number of sites: 46
Each neighbourhood is randomised to receive either mobile clinic or door-to-door enquiry.

Open cohort of all adults living in households within study neighbourhoods (~120,000 in total). Stratified randomisation according to pre-intervention TB case-notification rates.

As of 13/02/2007 the anticipated end date of this trial was shortened to the 1st December 2008. This trial is closed to recruitment: follow up continuing
Primary outcome measure(s) Cumulative yield of TB cases detected through six rounds of periodic (six-monthly) case-finding intervention delivered through either:
1. House-to-house enquiry for chronic coughers
2. Mobile diagnostic clinic visits
Secondary outcome measure(s) HIV-specific point prevalence and incidence of active TB disease before and immediately after the intervention (for whole study area with both arms combined) - as of 13/02/2007 this secondary outcome measure was changed to: 'Point prevalence of culture-positive TB disease before and immediately after the intervention (for whole study area with both arms combined)'.
Sources of funding The Wellcome Trust (UK) (grant ref: 074644)
Trial website
Publications 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20923715
Contact name Dr  E  Corbett
  Address London School of Hygiene and Tropical Medicine
Department of Infectious and Tropical Diseases
Keppel Street
  City/town London
  Zip/Postcode WC1E 7HT
  Country United Kingdom
  Tel +44 (0)20 7927 2116
  Fax +44 (0)20 7637 4314
  Email elizabeth.corbett@lshtm.ac.uk
Sponsor London School of Hygiene and Tropical Medicine (UK)
  Address Keppel Street
  City/town London
  Zip/Postcode WC1E 7HT
  Country United Kingdom
  Tel +44 (0)20 7636 8636
  Fax +44 (0)20 7637 4314
  Email Penny.Ireland@lshtm.ac.uk
  Sponsor website: http://www.lshtm.ac.uk/
Date applied 14/10/2005
Last edited 21/03/2013
Date ISRCTN assigned 14/10/2005
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