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Machine perfusion preservation versus cold storage of cadaveric kidneys for transplantation
DOI 10.1186/ISRCTN83876362
ClinicalTrials.gov identifier
EudraCT number
Public title Machine perfusion preservation versus cold storage of cadaveric kidneys for transplantation
Scientific title
Acronym Machine Preservation Trial
Serial number at source TR 811/1-1
Study hypothesis Machine perfusion reduces the rate of delayed graft function following kidney transplantation compared to cold storage
Lay summary Not provided at time of registration
Ethics approval Not provided at time of registration
Study design Randomised controlled trial
Countries of recruitment Germany, Netherlands
Disease/condition/study domain Kidney insufficiency
Participants - inclusion criteria Every deceased donor older than 15 years will be included
Participants - exclusion criteria Combined transplantations
Anticipated start date 01/11/2005
Anticipated end date 31/10/2006
Status of trial Completed
Patient information material
Target number of participants 300 donors, 600 recipients
Interventions One kidney of each donor is randomised to machine perfusion, the other kidney will be cold stored
Primary outcome measure(s) Delayed graft function defined by necessity of dialysis in the first 7 days post transplant
Secondary outcome measure(s) 1. Decrease of creatinine
2. Rejection rates
3. Graft survival
4. Economics
Sources of funding 1. Organ Recovery Systems Inc. (USA)
2. German Research Foundation (Deutsche Forschungsgemeinschaft) (DFG) (Germany)
Trial website
Publications 1. 2009 results in http://www.ncbi.nlm.nih.gov/pubmed/19118301
2. 2011 results in http://www.ncbi.nlm.nih.gov/pubmed/21332580
Contact name Prof  Rutger J  Ploeg
  Address University Medical Center
Deparment of Surgery
PO Box 30001
  City/town Groningen
  Zip/Postcode 9700 RB
  Country Netherlands
  Tel +31 (0)50 3614430
  Fax +31 (0)50 3614873
  Email r.j.ploeg@chir.umcg.nl
Sponsor Organ Recovery Systems Inc. (USA)
  Address 2570 East Devon avenue
  City/town Des Plaines
  Zip/Postcode IL 60018
  Country United States of America
  Email lrodgers@organ-recovery.com
  Sponsor website: http://www.organ-recovery.com
Date applied 14/09/2005
Last edited 06/09/2011
Date ISRCTN assigned 25/01/2006
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