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ISRCTN
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ISRCTN81212339
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ClinicalTrials.gov identifier
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Public title
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Clinical benefits of additional resistance-type exercise during an endurance-type exercise intervention in coronary artery disease patients
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Scientific title
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Clinical benefits of additional resistance-type exercise during an endurance-type exercise intervention in coronary artery disease patients: a randomised controlled trial
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Acronym
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STIMCARE
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Serial number at source
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07.48/cardio07.081
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Study hypothesis
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We hypothesise that by adding resistance-type exercise during an endurance-type exercise intervention, significantly greater clinical benefits are achieved in coronary artery disease patients.
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Lay summary
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Ethics approval
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Medical Ethical Committee of Jessa Hospital approved on the 29th January 2007 (ref: 07.48/cardio07.081)
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Study design
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Prospective randomised clinical trial
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Countries of recruitment
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Belgium
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Disease/condition/study domain
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Coronary artery disease
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Participants - inclusion criteria
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60 coronary artery disease (CAD) patients (aged between 45 - 80 years, either sex) agreed to participate in this study.
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Participants - exclusion criteria
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1. Complicated hospitalisation (renal failure, sepsis)
2. Delayed and/or complicated sternum healing
3. Hypertension (greater than 150 mmHg systolic blood pressure at rest and/or greater than 250 mmHg systolic blood pressure during exercise)
4. Presence of pulmonary and renal co-morbidity
5. Peripheral artery disease
6. Orthopaedic limitations
7. Subjects presenting myocardial ischaemia and/or severe ventricular arrhythmias during baseline exercise testing
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Anticipated start date
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01/02/2008
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Anticipated end date
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01/03/2010
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Status of trial
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Completed |
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Patient information material
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Not available in web format, please use the contact details below to request a patient information sheet
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Target number of participants
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60
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Interventions
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All subjects exercised under close supervision of experienced physiotherapists three days per week for a total duration of six weeks in the cardiac rehabilitation centre of the hospital. Exercise training intensity was determined by baseline VO2 peak assessment: subjects exercised at a heart rate corresponding to 65% of baseline VO2 peak, for 40 minutes each exercise training session (17 minutes cycling, 13 minutes walking, 10 minutes arm cranking). Subjects were randomly (by coin) assigned to an endurance-training group, or combined endurance and strength-training group.
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Primary outcome measure(s)
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1. Maximal exercise capacity
2. Sub-maximal exercise capacity
3. Muscle strength
4. Blood plasma lipid profile and glycaemic control
5. Habitual activity level
These measurements were executed at entry of rehabilitation, and after 7 weeks of rehabilitation.
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Secondary outcome measure(s)
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1. Blood endothelial progenitor cell
2. Cytokine content
These measurements were executed at entry of rehabilitation, and after 7 weeks of rehabilitation.
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Sources of funding
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Heart Centre Hasselt vzw (Belgium)
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Trial website
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Publications
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Contact name
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Dr
Dominique
Hansen
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Address
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Jessa Hospital
Stadsomvaart 11
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City/town
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Hasselt
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Zip/Postcode
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3500
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Country
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Belgium
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Sponsor
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Heart Centre Hasselt vzw (Belgium)
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Address
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Begeveldstraat
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City/town
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Bilzen
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Zip/Postcode
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3740
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Country
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Belgium
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Sponsor website:
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http://www.jessazh.be/
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Date applied
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14/01/2010
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Last edited
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09/02/2010
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Date ISRCTN assigned
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09/02/2010
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