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Care for depression in people with diabetes and/or coronary heart disease
ISRCTN ISRCTN80309252
DOI 10.1186/ISRCTN80309252
ClinicalTrials.gov identifier
EudraCT number
Public title Care for depression in people with diabetes and/or coronary heart disease
Scientific title COllaborative INterventions for CIrculation and DEpression (COINCIDE): Care for depression in people with diabetes and/or coronary heart disease
Acronym COINCIDE
Serial number at source 11201
Study hypothesis Depression is a prevalent issue for patients suffering from long term conditions (LTC) such as diabetes or coronary heart disease. Patients who experience depression alongside a LTC may find it more difficult to manage their illness properly and experience a poorer standard of health. Effective treatments for depression are available but are under-prescribed for patients with LTCs as depression is frequently undetected and may be viewed by both patients and health professionals as a normal consequence of ill health.

The COINCIDE trial will test the effectiveness of collaborative care in the UK for patients with depression and a long-term condition.

More details can be found at http://public.ukcrn.org.uk/Search/StudyDetail.aspx?StudyID=11201
Lay summary Lay summary under review 3
Ethics approval Preston MRES North West, 28 October 2011 ref: 11/NW/0742
Study design Randomised interventional treatment
Countries of recruitment United Kingdom
Disease/condition/study domain Depression
Participants - inclusion criteria 1. Patients aged 18 or over
2. Are listed on GP practice QOF registers with a diagnosis of coronary heart disease and/or Type 1 or Type 2 diabetes
3. Have persistent depressive symptoms (>10 on Patient Health Questionnaire PHQ9).
4. Patients who are already receiving antidepressant medication or psychotherapy but who still score >10 on the PHQ9.
5. We will also include non-English speaking patients of South Asian origin
6. Male and female participants
Participants - exclusion criteria 1. Aged less than 18 years old
2. Refused to consent
3. GP has removed them from the diabetes/CHD database
4. Suffer from a severe and enduring mental disorder
5. At risk of suicide and require immediate care from a crisis management team
6. If their depression is linked to bereavement
Anticipated start date 01/01/2012
Anticipated end date 01/01/2013
Status of trial Completed
Patient information material Not available in web format, please use the contact details below to request a patient information sheet
Target number of participants UK Sample Size: 450
Interventions The trial is being run by the University of Manchester and will recruit 450 patients from 30 general practices in the North West of the UK. Patients will be recruited who have signs of depression as well as depression and/or diabetes. General practices will be randomised to give their patients collaborative care or usual care. We will measure levels of depression at study entry and at six month follow-up to evaluate if patients receiving collaborative care have lower levels of depression, compared to those that received usual care. The trial will also evaluate the extent to which patients have utilised health care services and examine the cost-effectiveness of collaborative care.

Followed up at 6 months.
Primary outcome measure(s) SCL90 depression scale measured at 6 months
Secondary outcome measure(s) Patient Health Questionnaire (PHQ-9) measured at 6 months
Sources of funding National Institute for Health Research (NIHR) - CLAHRC (UK)
Trial website http://www.coincidehealth.co.uk
Publications 1. 2012 protocol in: http://www.ncbi.nlm.nih.gov/pubmed/22906179
2. 2013 protocol update in: http://www.ncbi.nlm.nih.gov/pubmed/23663556
Contact name Dr  Andrea  Cherrington
  Address Community Based Medicine
The University of Manchester
Williamson Building
Oxford Road
  City/town Manchester
  Zip/Postcode M13 9PL
  Country United Kingdom
  Tel +44 (0)161 306 7043
  Email Andrea.Cherrington@manchester.ac.uk
Sponsor University of Manchester (UK)
  Address c/o Lynne Macrae
Oxford Road
  City/town Manchester
  Zip/Postcode M13 9PL
  Country United Kingdom
  Tel +44 (0)161 306 6000
  Email Lynne.k.macrae@manchester.ac.uk
  Sponsor website: http://www.manchester.ac.uk/
Date applied 25/01/2012
Last edited 25/10/2013
Date ISRCTN assigned 25/01/2012
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