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Cranberry product versus low dose trimethoprim in the prevention of recurrent urinary infections in older women: a double blind randomised trial of effectiveness and acceptability
ISRCTN ISRCTN80031108
DOI 10.1186/ISRCTN80031108
ClinicalTrials.gov identifier
EudraCT number
Public title Cranberry product versus low dose trimethoprim in the prevention of recurrent urinary infections in older women: a double blind randomised trial of effectiveness and acceptability
Scientific title
Acronym N/A
Serial number at source 555555
Study hypothesis 1. What is the relative effectiveness of low dose trimethoprim compared to cranberry product in the prevention of urinary tract infections in older women with recurrent infections?
2. What is the acceptability of and adherence to both preventative treatments?
Lay summary
Ethics approval Approval granted by the Tayside Committee of Medical Research Ethics on 23rd March 2006 (ref: 06/S1402/23)
Study design Double-blind, randomised controlled trial
Countries of recruitment United Kingdom
Disease/condition/study domain Recurrent urinary tract infections
Participants - inclusion criteria Community dwelling women aged 45 years or over with at least two antibiotic-treated urinary tract infections or episodes of cystitis in the previous 12 months
Participants - exclusion criteria 1. Previous urological surgery, stone or anatomical abnormalities
2. Urinary catheter
3. Diabetes mellitus
4. Immunocompromised
5. Pyelonephritis
6. Severe renal impairment
7. Blood dyscrasia
8. Symptomatic urinary tract infection (UTI) at baseline
9. Cognitive impairment precluding informed consent
10. Resident in institutional care
11. On longterm antibiotics
12. On warfarin therapy
13. Regular cranberry consumers
14. Unwilling to participate
Anticipated start date 01/09/2006
Anticipated end date 31/08/2008
Status of trial Completed
Patient information material
Target number of participants 120
Interventions Trimethoprim 100 mg daily versus 500 mg cranberry product daily
Primary outcome measure(s) First recurrence of symptomatic urinary tract infection
Secondary outcome measure(s) Acceptability and adherence
Sources of funding Moulton Charitable Foundation (UK)
Trial website
Publications 2008 results in http://www.ncbi.nlm.nih.gov/pubmed/19042940
Contact name Prof  Marion  McMurdo
  Address Ageing and Health
Division of Medicine and Therapeutics
Ninewells Hospital and Medical School
  City/town Dundee
  Zip/Postcode DD1 9SY
  Country United Kingdom
Sponsor University of Dundee (UK)
  Address Research and Innovation Services
University of Dundee
  City/town Dundee
  Zip/Postcode DD1 4HN
  Country United Kingdom
Date applied 01/06/2006
Last edited 08/12/2008
Date ISRCTN assigned 13/06/2006
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