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Collaborative Care: Depression in Occupational Care
ISRCTN ISRCTN78462860
DOI 10.1186/ISRCTN78462860
ClinicalTrials.gov identifier
EudraCT number
Public title Collaborative Care: Depression in Occupational Care
Scientific title
Acronym CC:DOC
Serial number at source N/A
Study hypothesis A collaborative care intervention for patients with major depressive disorder who are on sick leave will result in more reduction in depressive symptoms and a faster return to work than usual care.
Lay summary Not provided at time of registration
Ethics approval Ethics approval received from the Ethics Committee of the VUmc (METc, VUmc, Amsterdam) on the 3rd August 2007 (ref: 2006/246).
Study design Randomised controlled parallel armed trial
Countries of recruitment Netherlands
Disease/condition/study domain Depressive disorders
Participants - inclusion criteria Employees on sick leave lasting between 4 to 12 weeks with major depressive disorder and who do not have the prospect of full return to work yet.
Participants - exclusion criteria 1. Patients who are suicidal, psychotic or have dementia, as noticed by the company doctor
2. Addicted to drugs or alcohol, as assessed by the Mini International Neuropsychiatric Interview (MINI)
3. Patients who do not speak Dutch sufficiently to fill in the questionnaires

Patients who are already receiving psychiatric treatment can be included in the study, in case of mutual agreement with the current care giver.
Anticipated start date 01/03/2007
Anticipated end date 01/06/2010
Status of trial Completed
Patient information material
Target number of participants 126
Interventions The intervention follows a collaborative care model with adherence and compliance enhancing techniques, contracting, Problem Solving Treatment (PST), antidepressant medication, a workplace intervention, and manual guided self help aimed at return to work and healthy lifestyle.
Primary outcome measure(s) The primary outcome measure is the extent of reduction in depressive symptoms, as measured by the PHQ-9.
Secondary outcome measure(s) The secondary outcome measure is time to return to work, which will be acquired upon inquiry with company doctor and patient and which refers to the duration of absence through illness until work is resumed.
Sources of funding Foundation Reserves Voormalige Vrijwillige Ziekenfondsverzekering (RVVZ) (The Netherlands)
Trial website
Publications 1. 2012 results in http://www.ncbi.nlm.nih.gov/pubmed/22116977
Contact name Ms  M C  Vlasveld
  Address Trimbos-instituut/Netherlands institute of Mental Health and Addiction
Da Costakade 45
P.O. Box 725
  City/town Utrecht
  Zip/Postcode 3500 AS
  Country Netherlands
  Tel +31 (0)30 2959303
  Email mvlasveld@trimbos.nl
Sponsor Trimbos-institute/Netherlands Institute of Mental Health and Addiction (The Netherlands)
  Address P.O. Box 725
  City/town Utrecht
  Zip/Postcode 3500 AS
  Country Netherlands
  Tel +31 (0)30 2971100
  Fax +31 (0)30 2971111
  Email info@trimbos.nl
  Sponsor website: http://www.trimbos.nl/default37.html
Date applied 01/12/2006
Last edited 23/08/2012
Date ISRCTN assigned 01/12/2006
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