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ISRCTN
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ISRCTN74348595
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DOI
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10.1186/ISRCTN74348595
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ClinicalTrials.gov identifier
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EudraCT number
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Public title
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Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine
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Scientific title
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Acronym
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SEARCH
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Serial number at source
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CTSU SEARCH1
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Study hypothesis
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Do larger reductions in blood cholesterol produce larger, and worthwhile, reductions in cardiovascular risk, and does homocysteine-lowering with folic acid and vitamin B12 reduce cardiovascular risk?
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Lay summary
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Coronary heart disease
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Participants - inclusion criteria
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Men and women who have survivied a heart attack and in whom statin therapy is indicated.
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Participants - exclusion criteria
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Age under 18 years or over 80 at invitation, contraindications to either study drug, other predominant medical problem.
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Anticipated start date
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30/07/1998
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Anticipated end date
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31/12/2007
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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12,064
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Interventions
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Simvastatin 80 mg versus 20 mg daily, and separately folic acid 2 mg plus 1 mg vitamin B12 daily or matching placebo tablets.
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Primary outcome measure(s)
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Major vascular events (MVEs) during the scheduled treatment period
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Secondary outcome measure(s)
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MVEs separately during the first year and in the later years of the study, MVEs in patients subdivided by pre-randomisation lipid levels, MVEs in the presence and absence of the other randomised treatments, major coronary events, total strokes
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Sources of funding
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A grant to Oxford University from Merck and Co.
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Trial website
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Publications
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1. 2008 results in http://www.ncbi.nlm.nih.gov/pubmed/18650507
2. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20571015
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Contact name
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Prof
Rory
Collins
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Address
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Clinical Trial Service Unit
Richard Doll Building
Old Road Campus
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City/town
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Oxford
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Zip/Postcode
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OX3 7LF
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Country
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United Kingdom
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Tel
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+44 (0)1865 743743
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Fax
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+44 (0)1865 743985
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Email
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Secretary@ctsu.ox.ac.uk
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Sponsor
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University of Oxford (UK)
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Address
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University Offices
Wellington Square
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City/town
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Oxford
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Zip/Postcode
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OX1 2JD
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Country
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United Kingdom
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Tel
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+44 (0)1865 270000
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Fax
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+44 (0)1865 270708
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Email
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search@ctsu.ox.ac.uk
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Sponsor website:
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http://www.ox.ac.uk
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Date applied
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15/08/2005
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Last edited
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24/06/2010
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Date ISRCTN assigned
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09/09/2005
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