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Preventive Angioplasty in Myocardial Infarction Trial
ISRCTN ISRCTN73028481
DOI 10.1186/ISRCTN73028481
ClinicalTrials.gov identifier
EudraCT number
Public title Preventive Angioplasty in Myocardial Infarction Trial
Scientific title Preventive Angioplasty in Myocardial Infarction Trial: a randomised controlled trial
Acronym PRAMI
Serial number at source 07/H0703/109
Study hypothesis A randomised trial among patients with an acute myocardial infarction (AMI) undergoing a therapeutic angioplasty (a procedure to unblock the artery causing the AMI), to determine the value of preventive angioplasty (additional angioplasty to dilate all other narrowed coronary arteries that were not the cause of the AMI but may cause a future infarct) undertaken as an immediate follow-on procedure.
Lay summary Not provided at time of registration
Ethics approval East London and the City Research Ethics Committee approved in December 2007
Study design Randomised controlled trial
Countries of recruitment United Kingdom
Disease/condition/study domain Coronary artery disease
Participants - inclusion criteria Patients (no age limits, either sex) with acute myocardial infarction undergoing a therapeutic angioplasty to the infarct related artery
Participants - exclusion criteria 1. Cardiogenic shock
2. Coronary artery bypass graft (CABG)
Anticipated start date 14/04/2008
Anticipated end date 14/04/2012
Status of trial Completed
Patient information material Not available in web format, please use the contact details below to request a patient information sheet
Target number of participants 600
Interventions Six hundred patients with AMI will be allocated at random to receive therapeutic angioplasty alone or therapeutic angioplasty plus preventive angioplasty undertaken as an immediate follow-on procedure. Patients will be followed up for an average of 3 years.
Primary outcome measure(s) All outcomes will be recorded during the period of follow up and analysed 1 year after the last patient is recruited:
1. Death
2. Non-fatal MI
3. Refractory angina
Secondary outcome measure(s) All outcomes will be recorded during the period of follow up and analysed 1 year after the last patient is recruited:
1. Repeat revascularisation
2. Complications of angioplasty
3. Angina score
4. EQ510
5. Economic evaluation
Sources of funding Bart's and the London Trust (BLT) Charitable Foundation (UK)
Trial website http://www.wolfson.qmul.ac.uk/epm/research/prami/index.html
Publications 2013 results in: http://www.ncbi.nlm.nih.gov/pubmed/23991625
Contact name Dr  David  Wald
  Address Wolfson Institute of Preventive Medicine
Charterhouse Square
  City/town London
  Zip/Postcode EC1M 6BQ
  Country United Kingdom
Sponsor Queen Mary University of London (UK)
  Address Clinical Operations Manager
Joint R & D Office
Barts and the London Trust/Barts and the London School of Medicine & Dentistry
QM Innovation Centre
5 Walden Street
  City/town London
  Zip/Postcode E1 2EF
  Country United Kingdom
  Sponsor website: http://www.qmul.ac.uk/
Date applied 25/08/2009
Last edited 27/09/2013
Date ISRCTN assigned 07/10/2009
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