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ISRCTN
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ISRCTN72673620
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ClinicalTrials.gov identifier
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Public title
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Manchester Asthma and Allergy Study
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Scientific title
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Acronym
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MAAS
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Serial number at source
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N/A
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Study hypothesis
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Birth cohort study investigating the development of asthma and allergic disease
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Lay summary
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Ethics approval
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Age 0 - 5 years follow up, ERP/94/032, approval received on 24/03/1994. Age 5 - 8 years follow up, SOU/00/258 and SOU/00/259, approval received on 20/12/2000. Age 8 - 11 years follow up, 03/SM/400, approval received on 05/12/03
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Study design
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Prospective, observational, birth cohort study
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Asthma and allergy
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Participants - inclusion criteria
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Children born at Wythenshawe Hospital, Manchester and Stepping Hill Hospital, Stockport between January 1996 and April 1998
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Participants - exclusion criteria
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Premature birth <32 weeks gestation
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Anticipated start date
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01/09/1995
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Anticipated end date
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01/06/2019
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Status of trial
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Ongoing |
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Patient information material
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Target number of participants
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1250
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Interventions
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This is a prospective, observational birth cohort study, which includes investigating environmental exposures, immune responses, behaviour or family functioning, genetic epidemiology, pulmonary physiology and clinical outcomes
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Primary outcome measure(s)
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1. Asthma at age 5, 8, 11 and 14 years
2. Sensitisation at age 1, 3, 5, 8, 11 and 14 years
3. Allergies (e.g. hay fever) at age 5, 8, 11 and 14 years
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Secondary outcome measure(s)
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1. Wheeze and eczema at age 1, 3, 5, 8, 11 and 14 years
2. Healthcare utilisation by age 8 - 11 years
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Sources of funding
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1. Asthma UK (UK)
2. Moulton Charitable Trust (UK)
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Trial website
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Publications
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1. 2008 results in http://www.ncbi.nlm.nih.gov/pubmed/18356563
2. 2008 results in http://www.ncbi.nlm.nih.gov/pubmed/20167852
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Contact name
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Prof
Adnan
Custovic
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Address
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North West Lung Research Centre
Wythenshawe Hospital
Southmoor Road
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City/town
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Manchester
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Zip/Postcode
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M23 9LT
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Country
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United Kingdom
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Tel
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+44 (0)161 291 2494
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Fax
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+44 (0)161 291 5057
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Email
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adnan.custovic@manchester.ac.uk
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Sponsor
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Wythenshawe Hospital (UK)
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Address
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c/o Andrew Maines
Research and Development Directorate
ERC Building
Wythenshawe Hospital
Southmoor Road
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City/town
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Manchester
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Zip/Postcode
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M23 9LT
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Country
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United Kingdom
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Tel
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+44 (0)161 291 5775
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Fax
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+44 (0)161 291 5771
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Email
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andrew.maines@manchester.ac.uk
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Date applied
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18/04/2006
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Last edited
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16/07/2010
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Date ISRCTN assigned
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05/05/2006
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