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Arrest 8: maximizing cardiopulmonary resuscitation (CPR) during the use of the automatic external defibrillator
ISRCTN ISRCTN72257677
DOI 10.1186/ISRCTN72257677
ClinicalTrials.gov identifier
EudraCT number
Public title Arrest 8: maximizing cardiopulmonary resuscitation (CPR) during the use of the automatic external defibrillator
Scientific title
Acronym N/A
Serial number at source NTR652
Study hypothesis 1. There is a significant increase in the time spent on chest compressions and rescue breathing using new designed voice-prompts
2. There is, similar to animal studies, a positive trade-off in immediate survival from these changes
Lay summary
Ethics approval Not provided at time of registration
Study design Randomized controlled trial
Countries of recruitment Netherlands
Disease/condition/study domain Out-of-hospital cardiac arrest (OHCA)
Participants - inclusion criteria All patients in out-of-hospital cardiac arrest (OHCA) in the study area, to whom a study automatic external defibrillator (AED) is applied, are included from the study
Participants - exclusion criteria 1. Resuscitations because of trauma
2. Persons below the age of 8
3. Ambulance already present when circulatory arrest occurs
Anticipated start date 01/06/2006
Anticipated end date 01/06/2009
Status of trial Completed
Patient information material
Target number of participants 392
Interventions Altering the voice-prompts of the AED in such a way that more CPR can be given during resuscitation. Setting of AED (regular voice prompts versus new voice-prompts cannot be identified before patient is connected to the AED. After that randomization is unblinded as the next voiceprompts are different.
Primary outcome measure(s) Admission alive in the hospital in intensive care unit (ICU) or critical care unit (CCU) or at intervention procedure, after restoration of spontaneous circulation (ROSC).
Secondary outcome measure(s) 1. The increase of total time spent on chest compressions and rescue breathing, expressed as a percentage of total connection time of the AED before return of spontaneous circulation (ROSC)
2. Amount of chest compressions given during the AED connection time before ROSC
3. Moment of the return of organized rhythm (ROOR), in this case, ROOR during AED use
4. Rate of recurrence of VF
5. Discharged alive from the hospital
6. Overall performance categories/cerebral performance categories (OPC/CPC) score on discharge from the hospital
Sources of funding Medtronic BV (Netherlands)
Trial website
Publications 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20042768
Contact name Mr  J.  Berdowski
  Address Academic Medical Center (AMC)
Department of Cardiology
F3-241
P.O. Box 22660
  City/town Amsterdam
  Zip/Postcode 1100 DD
  Country Netherlands
  Tel +31 (0)20 5669111
  Email j.berdowski@amc.uva.nl
Sponsor Academic Medical Center (AMC) (The Netherlands)
  Address P.O. Box 22660
  City/town Amsterdam
  Zip/Postcode 1100 DD
  Country Netherlands
Date applied 07/06/2006
Last edited 15/03/2010
Date ISRCTN assigned 07/06/2006
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