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ISRCTN
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ISRCTN63558189
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ClinicalTrials.gov identifier
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Public title
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Manchester Asthma and Allergy Study - primary prevention of asthma and allergy by allergen avoidance in high risk infants
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Scientific title
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Manchester Asthma and Allergy Study - primary prevention of asthma and allergy by allergen avoidance in high risk infants: a randomised controlled trial
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Acronym
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MAAS
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Serial number at source
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N/A
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Study hypothesis
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Living in a low allergen environment reduces the risk of primary sensitisation and the development of atopic disease in children at high risk
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Lay summary
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Ethics approval
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South Manchester Research Ethics Committee gave approval on the 24th March 1994 (ref: WJP/CMI/ERP/94/032)
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Asthma
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Participants - inclusion criteria
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High risk children (both parents atopic) of either sex born at Wythenshawe Hospital Manchester and Stepping Hill Hospital Stockport between January 1996 and April 1998.
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Participants - exclusion criteria
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Premature birth less than 32 weeks gestation.
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Anticipated start date
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01/09/1995
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Anticipated end date
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01/06/2019
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Status of trial
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Ongoing |
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Patient information material
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Not available in web format, please use the contact details below to request a patient information sheet
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Target number of participants
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300
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Interventions
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House dust mite allergen avoidance versus no intervention.
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Primary outcome measure(s)
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1. Asthma at age 5, 8, 11, and 14 years
2. Sensitisation at age 1, 3, 5, 8, 11 and 14 years
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Secondary outcome measure(s)
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Wheeze and eczema at age 1, 3, 5, 8, 11 and 14 years.
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Sources of funding
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1. Asthma UK (UK)
2. Moulton Charitable Trust (UK)
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Trial website
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Publications
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1. 2001 results in http://www.ncbi.nlm.nih.gov/pubmed/11476835
2. 2004 environmental control results in http://www.ncbi.nlm.nih.gov/pubmed/15142868
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Contact name
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Prof
Adnan
Custovic
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Address
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North West Lung Research Centre
Wythenshawe Hospital
Southmoor Road
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City/town
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Manchester
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Zip/Postcode
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M23 9LT
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Country
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United Kingdom
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Tel
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+44 (0)161 291 2494
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Fax
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+44 (0)161 291 5057
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Email
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adnan.custovic@manchester.ac.uk
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Sponsor
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Wythenshawe Hospital (UK)
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Address
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c/o Andrew Maines
R&D Directorate
ERC Building
Wythenshawe Hospital
Southmoor Road
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City/town
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Manchester
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Zip/Postcode
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M23 9LT
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Country
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United Kingdom
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Tel
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+44 (0)161 291 5775
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Fax
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+44 (0)161 291 5771
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Email
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andrew.maines@manchester.ac.uk
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Date applied
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26/09/2005
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Last edited
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09/02/2009
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Date ISRCTN assigned
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19/10/2005
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