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Stemming the Tide of Antibiotic Resistance: a trial of an intervention addressing the 'why' and 'how' of appropriate antibiotic prescribing in general practices
ISRCTN ISRCTN63355948
DOI 10.1186/ISRCTN63355948
ClinicalTrials.gov identifier
EudraCT number
Public title Stemming the Tide of Antibiotic Resistance: a trial of an intervention addressing the 'why' and 'how' of appropriate antibiotic prescribing in general practices
Scientific title
Acronym STAR
Serial number at source G0500956
Study hypothesis To examine if exposing prescribers in general practices to the STAR Educational Programme results in fewer antibiotics being dispensed to the practice's patients.
Lay summary Not provided at time of registration
Ethics approval Not provided at time of registration
Study design Cluster-randomised trial with randomisation and analysis at the level of general practice/general practitioner.
Countries of recruitment United Kingdom
Disease/condition/study domain Infections
Participants - inclusion criteria There are no inclusion or exclusion criteria, other than that we aim for two thirds of prescribers in each practice must agree to take part in the study. Practices will be approached at random and randomised in a way that balances for practice size and prior antibiotic prescribing.
Participants - exclusion criteria N/A
Anticipated start date 01/06/2006
Anticipated end date 30/11/2009
Status of trial Completed
Patient information material Not available in web format, please use the contact details below to request a patient information sheet
Target number of participants Up to 60 practices (approximately 140-180 clinicians)
Interventions Clinicians in practices randomised to the experimential condition will be exposed to the STAR Educational Program. This involves unique use of practices' own prescribing and resistance data and novel consulting strategies. Both the 'why' and 'how' of change will be addressed. Training methods will include: seminars, software supported, self-directed learning, and reflecting on video and actual consultations.

Control practices will be offered the intervention after the initial one year follow-up of the experimental practices is complete.
Primary outcome measure(s) Change in the total number of dispensed oral antibiotics (with examination of trend by quarter) per 1000 registered patients, for the year subsequent to the practice being exposed to the STAR programme, compared to the previous year, using PARC data.
Secondary outcome measure(s) Not provided at time of registration
Sources of funding Medical Research Council (MRC)(ref. no: G0500956) (UK)
Trial website
Publications 1. 2010 results in http://www.ncbi.nlm.nih.gov/pubmed/20459655
2. 2012 results in http://www.ncbi.nlm.nih.gov/pubmed/22302780
Contact name Prof  Christopher  Butler
  Address Dept of General Practice
Cardiff University
3rd Floor Neuadd Merionnyd
Healh Park
  City/town Cardiff
  Zip/Postcode CF14 4XN
  Country United Kingdom
  Email butlercc@cf.ac.uk
Sponsor Cardiff University (UK)
  Address Heath Park
  City/town Cardiff
  Zip/Postcode CF14 4XN
  Country United Kingdom
  Email davieskp2@cf.ac.uk
  Sponsor website: http://www.cardiff.ac.uk
Date applied 26/06/2006
Last edited 22/05/2012
Date ISRCTN assigned 22/08/2006
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