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ISRCTN
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ISRCTN57375471
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ClinicalTrials.gov identifier
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Public title
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Towards rational prescribing of antibiotics for acute rhinosinusitis: evaluation of the impact and costs of implementation strategies based on a multidisciplinary evidence-based guideline
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Scientific title
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Acronym
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N/A
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Serial number at source
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F6/12 - AV - F 681
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Study hypothesis
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In Belgium consumption of antibiotics is among the highest in Europe. As a result antimicrobial resistance rates are alarming. Recently a number of evidence-based guidelines on rational use of antibiotics have been produced and disseminated by the scientific organisations in collaboration with the Belgian Co-ordinating Committee for Antibiotic Policy. International research has shown that merely distributing guidelines to professionals in the field does not lead to behaviour change. In Belgium several strategies for implementation of good clinical practice, i.e. local peer review groups and academic detailing, have been initiated. However, the (local) effectiveness and cost-effectiveness of these strategies has not been evaluated. This project will investigate the impact of each of the strategies separately and the combination of both strategies in general practice, following the publication of a guideline on the management of acute rhinosinusitis. This guideline aims at rationalizing (i.e. reducing) the prescription rate for this condition in primary care.
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Lay summary
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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Belgium
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Disease/condition/study domain
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Implementation of a practice guideline for acute rhinosinusitis in general practice
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Participants - inclusion criteria
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Local peer review groups of general practitioners in Flanders, Belgium (approximately 10-20 GPs per group) are invited to participate.
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Participants - exclusion criteria
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Groups that have participated in the field testing of the guideline, groups that have been visited by academic detailers more than once in the past, groups located at >1 hour drive from the study centres.
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Anticipated start date
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01/07/2004
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Anticipated end date
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30/06/2005
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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135 patient registrations are aimed for in each study arm
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Interventions
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Cluster randomised factorial trial with 4 study arms.
Interventions: academic detailing visits to individual GPs and/or group sessions of GPs on the key messages of the guideline.
Control: no specific intervention
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Primary outcome measure(s)
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Antibiotic prescription rate, cost-effectiveness.
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Secondary outcome measure(s)
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Choice of antibiotic, use of personalized non-drug prescriptions, clinical course of rhinosinusitis as reported in patient diaries.
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Sources of funding
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Federal Belgian Ministry of Health and Fund for Scientific Research Flanders, Dossier nr. G.0617.05
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Trial website
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Publications
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Results: http://www.ncbi.nlm.nih.gov/pubmed/17545346
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Contact name
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Prof
Marc
De Meyere
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Address
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De Pintelaan 185 1K3
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City/town
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Ghent
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Zip/Postcode
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B-9000
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Country
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Belgium
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Email
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marc.demeyere@ugent.be
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Sponsor
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Fund for Scientific Research, Flanders (Belgium)
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Address
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Egmontstraat 5
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City/town
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Brussels
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Zip/Postcode
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B-1000
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Country
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Belgium
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Date applied
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18/03/2005
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Last edited
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15/04/2008
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Date ISRCTN assigned
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25/07/2005
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