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iQuit in practice: a study to examine a personalised web-and text message programme to support smoking cessation in Primary Care
ISRCTN ISRCTN56702353
DOI 10.1186/ISRCTN56702353
ClinicalTrials.gov identifier
EudraCT number
Public title iQuit in practice: a study to examine a personalised web-and text message programme to support smoking cessation in Primary Care
Scientific title A randomised controlled trial to assess the feasibility, acceptability and effectiveness of tailored web- and text-based facilitation of smoking cessation in primary care
Acronym N/A
Serial number at source N/A
Study hypothesis The proposed trial is part of a larger programme of work in the General Practice and Primary Care Research Unit, University of Cambridge, on computer-based approaches to smoking cessation. The intervention to be evaluated in this trial consists of two components:
1. A web-based program designed to be used by a practice nurse or other smoking cessation advisor (SCA); the program generates a cessation advice report that is highly tailored to relevant characteristics of the smoker
2. A three-month program of automatically generated tailored text messages sent to the smokerís mobile phone

The iQuit program is a potentially cost-effective approach which is designed to enhance the effectiveness of the consultation without requiring nurses to radically change the way they advise and treat smokers and to provide continuing support to smokers during their quit attempts, while reducing the need for them to attend the practice (except for the purpose of obtaining further supplies of nicotine replacement and attending for the routine NHS four-week follow-up appointment).
Lay summary Not provided at time of registration
Ethics approval Not provided at time of registration
Study design Two parallel group randomised controlled trial
Countries of recruitment United Kingdom
Disease/condition/study domain Smoking cessation
Participants - inclusion criteria Patients can be included in the study if they meet all of the criteria below:
1. Current smoker (has smoked in the 7 days prior to randomisation date)
2. Able to read English and can provide written informed consent
3. Is seriously considering quitting smoking and is willing to set a quit date within the 14 days after randomisation
4. Aged 18 - 75 years, either sex
5. Has a mobile phone and is familiar with sending and receiving SMS text messages
6. Is willing to participate in study and follow study procedures
7. Is not currently enrolled in another formal smoking cessation study or program
8. Is not using nicotene replacement therapy (NRT), bupropion (Zyban®) and varenicline (Champix®) or other pharmacotherapy at randomisation date
Participants - exclusion criteria 1. Do not meet all of the inclusion criteria
2. Considered by their GP to be unsuitable for the project for any reason e.g. people with severe mental impairment or severely or terminally ill

Co-morbidities, for example chronic obstructive pulmonary disease (COPD), diabetes, are not excluded from the study (unless their GP considers them unsuitable). In addition, we would not exclude entry to the trial of more than one participant per household, however, should this occur, they would be assigned to the same treatment group (to minimise the potential for contamination).
Anticipated start date 01/04/2009
Anticipated end date 31/01/2011
Status of trial Completed
Patient information material Not available in web format, please use the contact details below to request a patient information sheet
Target number of participants Total approx 600 (300 in each of the intervention groups)
Interventions Two groups to be compared:
1. Control group: participants will receive 'usual care' for smoking cessation
2. Intervention group: participants will receive 'usual care' for smoking cessation, plus a printed patient-tailored advice report generated by web-based software, followed by a 90-day program of patient-tailored interactive SMS text messages

Follow up dates:
Routine NHS follow up: 4 weeks from quit date
Research follow up: 8 weeks and 6 months from randomisation date
Primary outcome measure(s) Self-reported effectiveness, using a self report of being abstinent from smoking for at least 2 weeks, at 8-week follow-up from randomisation date, as assessed by postal questionnaire or telephone interview (blinded interviewer).
Secondary outcome measure(s) 1. Carbon monoxide (CO)-verified self-report of being abstinent from smoking for at least 2 weeks, at 4-week follow-up from quit date
2. Self-reported prolonged abstinence (at least 3 months) at 6-month follow-up from randomisation date
Sources of funding National Institute for Health Research (NIHR) (UK) - School for Primary Care Research (SPCR) (ref: 4.29)
Trial website
Publications 2013 protocol in http://www.ncbi.nlm.nih.gov/pubmed/23575031
Contact name Prof  Stephen  Sutton
  Address General Practice & Primary Care Research Unit
Department of Public Health & Primary Care
University of Cambridge, Institute of Public Health
Forvie Site, Robinson Way
  City/town Cambridge
  Zip/Postcode CB2 0SR
  Country United Kingdom
Sponsor University of Cambridge (UK)
  Address Research Services Division
16 Mill Lane
  City/town Cambridge
  Zip/Postcode CB2 1SB
  Country United Kingdom
  Sponsor website: http://www.rsd.cam.ac.uk/
Date applied 23/12/2008
Last edited 07/05/2013
Date ISRCTN assigned 02/03/2009
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