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ISRCTN
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ISRCTN55725285
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ClinicalTrials.gov identifier
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Public title
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A novel approach to treatment of hypertension in diabetic patients - A multicenter, double-blind, randomised study comparing the efficacy of combination therapy of Eprosartan versus Ramipril with low-dose Hydrochlorothiazide and Moxonidine on blood pressure levels in patients with hypertension and associated diabetes mellitus type 2 - rationale and design.
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Scientific title
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Acronym
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ASTRID (Antihypertensive treatment of Systolic/diastolic hypertension comparing Teveten and Ramipril and type 2 Diabetics)
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Serial number at source
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S171.3.012
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Study hypothesis
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Not provided at time of registration
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Lay summary
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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Germany, United Kingdom
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Disease/condition/study domain
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Essential Hypertension grade I and II
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Participants - inclusion criteria
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Investigative centers from eight European countries and Canada (primary and secondary care) targeting patients with grade I - II hypertension and associated diabetes mellitus type 2. Goal blood pressure (BP) targeted: below 130/80 mmHg.
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Participants - exclusion criteria
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Not provided at time of registration
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Anticipated start date
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01/01/2004
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Anticipated end date
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01/01/2006
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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Not provided at time of registration
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Interventions
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Single, double- and triple- combination antihypertensive therapy, active controlled (monotherapy [eprosartan versus ramipril] followed by addition of hydrochlorothiazide as second agent and moxonidine as a third agent).
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Primary outcome measure(s)
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Not provided at time of registration
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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GPS Solvay Pharmaceuticals
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Trial website
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Publications
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Protocol in: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15461784
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Contact name
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Dr
Cornel
Pater
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Address
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Hans-Boeckler Allee 20
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City/town
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Hannover
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Zip/Postcode
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30173
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Country
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Germany
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Tel
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+49 (0)511 857 2074
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Fax
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+49 (0)511 857 2464
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Email
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cornel.pater@solvay.com
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Sponsor
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Solvay Pharmaceuticals (Germany)
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Address
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Hans-Boeckler Allee 20
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City/town
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Hannover
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Zip/Postcode
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30173
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Country
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Germany
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Date applied
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12/10/2004
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Last edited
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07/08/2007
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Date ISRCTN assigned
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12/10/2004
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