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ISRCTN
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ISRCTN55334531
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ClinicalTrials.gov identifier
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Public title
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Optimum platelet inhibition after coronary artery bypass surgery: a prospective, randomised trial comparing platelet aggregation using low- and medium-dose aspirin and clopidogrel
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Scientific title
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Acronym
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N/A
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Serial number at source
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N0542115296
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Study hypothesis
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To determine the most effective anti-platelet agent following coronary artery by pass grafting (CABG).
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Lay summary
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Coronary artery bypass grafting (CABG)
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Participants - inclusion criteria
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72 Patients and 36 controls will be recruited from patients proceeding to coronary artery bypass surgery.
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Participants - exclusion criteria
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Does not match inclusion criteria
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Anticipated start date
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28/08/2002
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Anticipated end date
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01/06/2004
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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108
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Interventions
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Patients will be randomised into treatment allocation to receive either 100 mg aspirin, 325 mg aspirin or identically encapsulated 75 mg clopidogrel daily for 5 days.
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Primary outcome measure(s)
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Platelet aggregation ratio at 5 days.
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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Cambridge Consortium - Papworth Hospital NHS Trust (UK) - Papworth Hospital Charitable Funds
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Trial website
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Publications
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2004 results in http://www.ncbi.nlm.nih.gov/pubmed/15354104
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Contact name
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Mr
Stephen
Large
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Address
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Surgical Unit Top Floor
Papworth Hospital NHS Trust
Papworth Everard
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City/town
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Cambridge
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Zip/Postcode
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CB3 8RE
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Country
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United Kingdom
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Sponsor
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Record provided by the NHS Trusts Clinical Trials Register - Department of Health (UK)
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Address
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The Department of Health
Richmond House
79 Whitehall
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City/town
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London
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Zip/Postcode
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SW1A 2NL
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Country
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United Kingdom
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Tel
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+44 (0)207 307 2622
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Fax
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+44 (0)207 307 2623
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Email
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dhmail@doh.gsi.org.uk
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Sponsor website:
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http://www.doh.gov.uk
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Date applied
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12/09/2003
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Last edited
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09/09/2009
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Date ISRCTN assigned
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12/09/2003
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