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ISRCTN
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ISRCTN55225822
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ClinicalTrials.gov identifier
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Public title
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Psychological mechanisms in suicidal behaviour
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Scientific title
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Acronym
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N/A
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Serial number at source
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PRG/06/01
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Study hypothesis
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This is a preliminary (explanatory) trial to assess the immediate effects of Mindfulness-based Cognitive Therapy (MBCT) on cognitive reactivity (the tendency to react to small changes in mood with a catastrophic and rapidly escalating pattern of suicidal thinking).
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Lay summary
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Ethics approval
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Not provided at time of registration.
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Suicidality
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Participants - inclusion criteria
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1. Aged 18 to 64
2. History of major depression with suicidal ideation and/or suicidal behaviour
3. Not currently depressed or suicidal (at least eight weeks symptom free)
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Participants - exclusion criteria
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1. Visually impaired
2. Not fluent in English
3. Habitual self-damaging acts
4. Bipolar disorder
5. Schizophrenia
6. Active substance abuse
7. Eating disorder
8. Primary Obsessive Compulsive Disorder (OCD)
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Anticipated start date
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01/05/2005
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Anticipated end date
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01/12/2005
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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12
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Interventions
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Treatment:
Mindfulness-Based Cognitive Therapy (MBCT): manualised, eight week treatment combining stress reduction techniques and cognitive therapy and Treatment As Usual (TAU)
Control:
Waiting List control and Treatment As Usual (TAU)
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Primary outcome measure(s)
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1. Depression
2. Frequency of thought suppression
3. Change in problem solving and future thinking following experimental induction of mood
4. Self-rated mindfulness
5. Discrepancy between actual and ideal self-guides
6. Specificity of autobiographical memory
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Secondary outcome measure(s)
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No secondary outcome measures
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Sources of funding
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The Wellcome Trust (UK) (grant ref: 067797)
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Trial website
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Publications
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2009 results in http://www.ncbi.nlm.nih.gov/pubmed/19254446
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Contact name
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Prof
J. Mark G.
Williams
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Address
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Oxford University
Department of Psychiatry
Warneford Hospital
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City/town
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Oxford
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Zip/Postcode
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OX3 7JX
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Country
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United Kingdom
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Tel
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+44 (0)1865 226445
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Fax
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+44 (0)1865 223948
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Email
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mark.williams@psych.ox.ac.uk
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Sponsor
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University of Oxford (UK)
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Address
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University Offices
Wellington Square
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City/town
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Oxford
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Zip/Postcode
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OX1 2JD
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Country
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United Kingdom
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Tel
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+44 (0)1865 270143
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Fax
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+44 (0)1865 280467
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Email
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researchservices@admin.ox.ac.uk
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Sponsor website:
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http://www.ox.ac.uk/
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Date applied
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03/03/2005
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Last edited
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10/05/2011
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Date ISRCTN assigned
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22/07/2005
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