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ISRCTN
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ISRCTN53308138
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ClinicalTrials.gov identifier
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Public title
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Does an intensive development procedure of multidisciplinary guidelines improve prescribing behaviour: a pre/post study with concurrent control group and a randomised subgroup
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Scientific title
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Acronym
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N/A
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Serial number at source
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N/A
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Study hypothesis
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Two hypotheses:
1. Dissemination of locally and multidisciplinairy developed guidelines can lead to a modest but relevant change of volumes of prescriptions in the desired direction
2. What is the additional effect on change of volumes of prescriptions because of involving the target group in the preparation and development of the guidelines
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Lay summary
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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Netherlands
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Disease/condition/study domain
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Improving rational prescribing behaviour among GPs in the Netherlands
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Participants - inclusion criteria
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Completeness of the GPs’ data (no missing data per GP for more than one year) and at least 500 patients in the GPs’ practice
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Participants - exclusion criteria
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GPs outside the region
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Anticipated start date
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01/02/2001
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Anticipated end date
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01/02/2004
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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All GPs in the region Maastricht (n = 53)
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Interventions
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The randomised intervention concerns the intensified involvement of GPs in the development procedure of a set of prescription guidelines. A randomised subgroup of GPs were invited for a more intense role and received conceptual guidelines to comment on them. The other GPs only received the final version of the prescription guidelines. The second design of our study, the quasi experiment, concerns the dissemination of locally and multidisciplinary guidelines in the south of the Netherlands, controlled by a comparable region elsewhere in the Netherlands. The guidelines contained 14 recommendations on antibiotics, asthma/COPD drugs and cholesterol drugs.
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Primary outcome measure(s)
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Prescription data, gathered retrospectively per GP per month during the period 2001-2004. Expected directions of change have been defined based on the detailed recommendations contained in the guidelines, in combination with estimates based on the expertise of the initially involved key regional representatives.
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Secondary outcome measure(s)
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Drug volumes and pre/post changes between groups on short-term and long term (one and two years after).
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Sources of funding
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The two local insurance companies (VGZ and CZ) provided funding sources for this study (Netherlands).
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Trial website
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Publications
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2006 results in http://www.ncbi.nlm.nih.gov/pubmed/17081285
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Contact name
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Prof
Johan L.
Severens
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Address
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Department of Health Organisation, Policy and Economics
P.O. Box 616
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City/town
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Maastricht
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Zip/Postcode
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6200 MD
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Country
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Netherlands
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Sponsor
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Care and Public Health Research Institute (CAPHRI) (Netherlands)
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Address
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P.O. Box 616
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City/town
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Maastricht
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Zip/Postcode
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6200 MD
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Country
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Netherlands
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Sponsor website:
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http://www.caphri.unimaas.nl
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Date applied
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20/09/2005
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Last edited
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10/09/2009
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Date ISRCTN assigned
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28/09/2005
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