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ISRCTN
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ISRCTN51663857
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ClinicalTrials.gov identifier
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Public title
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Anticoagulation following tissue aortic valve replacement
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Scientific title
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Acronym
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AFTAV
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Serial number at source
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06/Q0803/36
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Study hypothesis
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There is no difference in rates of neurological events following aortic valve replacement (AVR) with reference to oral anticoagulation
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Lay summary
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Ethics approval
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Ethics approval not yet received from Wandsworth Local Research Ethics Committee as of 10/04/06
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Study design
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Prospective randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Aortic valve disease
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Participants - inclusion criteria
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Patients undergoing tissue aortic valve replacement
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Participants - exclusion criteria
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1. Patients who require aspirin or warfarin therapy on established medical grounds
2. Patients unable to take warfarin or aspirin
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Anticipated start date
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01/05/2006
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Anticipated end date
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01/05/2007
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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400
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Interventions
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Three groups: warfarin therapy for 90 days, aspirin therapy for 90 days, control group (no medication)
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Primary outcome measure(s)
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1. Neurological events
2. Stroke
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Secondary outcome measure(s)
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Thrombus formation
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Sources of funding
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St George's Heart Science Fund
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Trial website
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Publications
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Contact name
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Dr
Justin
Nowell
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Address
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St George's Healthcare NHS Trust
Blackshaw Road
Tooting
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City/town
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London
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Zip/Postcode
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SW17 0QT
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Country
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United Kingdom
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Sponsor
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St George's Healthcare NHS Trust (UK)
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Address
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Blackshaw Road
Tooting
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City/town
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London
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Zip/Postcode
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SW17 0QT
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Country
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United Kingdom
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Date applied
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27/03/2006
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Last edited
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07/12/2010
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Date ISRCTN assigned
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10/04/2006
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