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ISRCTN
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ISRCTN47655040
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ClinicalTrials.gov identifier
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Public title
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The analgesic effect of parecoxib following total abdominal hysterectomy
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Scientific title
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Acronym
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N/A
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Serial number at source
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N0123138268
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Study hypothesis
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To investigate the analgesic effects and benefits of parecoxib.
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Lay summary
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Ethics approval
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Not provided at time of registration
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Post-operative pain
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Participants - inclusion criteria
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1. Patients having total abdominal hysterectomy
2. American Society of Anesthesiologists (ASA) 1-11
3. Aged 20 - 65, female
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Participants - exclusion criteria
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1. Patients having hysterectomy/morphine consumption
2. Pain
3. Sedation
4. Nausea
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Anticipated start date
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15/05/2002
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Anticipated end date
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01/04/2003
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Status of trial
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Completed |
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Patient information material
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Target number of participants
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21 controls/21 patients
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Interventions
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All patients were given intraoperative:
1. Propofol 2 - 4 mg kg intravenously (i.v.)
2. Morphine 10 mg i.v.
3. Prochlorperazine 12.5 mg intramuscularly (i.m.)
Patients' lungs were ventilated with nitrous oxide and isoflurane 1 - 1.5% in oxygen, and morphine was self-administered for postoperative analgesia via a patient controlled analgesia (PCA) device.
Patients were allocated randomly to receive either parecoxib 40 mg i.v. or normal saline on induction of anaesthesia.
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Primary outcome measure(s)
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1. Morphine consumption
2. Pain
3. Sedation
4. Nausea
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Secondary outcome measure(s)
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Not provided at time of registration
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Sources of funding
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1. University Hospitals of Leicester NHS Trust (UK)
2. Departmental funding
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Trial website
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Publications
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Results in http://www.ncbi.nlm.nih.gov/pubmed/12765890
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Contact name
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Dr
A
Ng
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Address
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University Hospitals of Leicester
University Hospitals of Leicester
c/o Research and Development Office
Leicester General Hospital NHS Trust
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City/town
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Leicester
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Zip/Postcode
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LE1 4PW
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Country
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United Kingdom
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Sponsor
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Record Provided by the NHSTCT Register - 2005 Update - Department of Health (UK)
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Address
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The Department of Health
Richmond House
79 Whitehall
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City/town
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London
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Zip/Postcode
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SW1A 2NL
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Country
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United Kingdom
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Tel
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+44 (0)20 7307 2622
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Fax
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+44 (0)20 7307 2623
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Email
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dhmail@doh.gsi.org.uk
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Sponsor website:
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http://www.dh.gov.uk/Home/fs/en
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Date applied
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30/09/2005
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Last edited
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14/04/2008
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Date ISRCTN assigned
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30/09/2005
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