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ISRCTN
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ISRCTN47558792
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ClinicalTrials.gov identifier
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Public title
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Reducing antibioic prescribing in respiratory illness
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Scientific title
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Cluster randomised trial in a Primary Care database: utilising electronic patient records for intervention research into reducing antibiotic prescribing in respiratory illness
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Acronym
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N/A
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Serial number at source
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086921; UKCRN ID: 7412
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Study hypothesis
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To test the effectiveness of an electronic record-based intervention at achieving a reduction in antibiotic prescribing at consultations for respiratory illness between the ages of ages 18 and 59 years in intervention practices as compared with controls.
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Lay summary
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Ethics approval
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London - Surrey Borders Research Ethics Committee approved on the 21st December 2009 (ref: 09/H0806/81)
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Study design
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Interventional multicentre cluster randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Respiratory tract infection
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Participants - inclusion criteria
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1. Patients aged 18 - 59 years, either sex
2. Registered at the practice for at least three years at the trial start date
3. First diagnosis of stroke recorded in the 24 month period before the trial start date
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Participants - exclusion criteria
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Younger than 18 years and over the age of 59 years
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Anticipated start date
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01/04/2010
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Anticipated end date
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31/10/2011
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Status of trial
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Completed |
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Patient information material
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Not available in web format, please use the contact details below to request a patient information sheet
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Target number of participants
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50 GP practices per group (100 practices in total)
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Interventions
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Electronic prompts have been developed based on recommended clinical practice guidelines to be activated during consultations for respiratory tract infection (RTI) in the selected age range. During consultations with patients presenting with symptoms of RTI, primary care professionals will see the prompts which remind them of recommended standards of care in RTI. The prompts will also provide them with supporting information and links to evidence that supports the recommendations. The decision on whether to follow the treatment suggestions included in the prompt, or whether to prescribe antibiotics, will be at the discretion of the GP. The GP will also be able to terminate display of the prompt at any time. As indicated above, the prompts will only be activated during consultations by patients aged 18 to 59 years. There will be no intervention at control practices. The intervention phase will continue for 12 months at each practice.
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Primary outcome measure(s)
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Proportion of RTI consultations with antibiotics prescribed over 12 months
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Secondary outcome measure(s)
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Measured at 12 months follow-up:
1. Age- and sex-specific rates of RTI consultation
2. Age- and sex-specific proportion of RTI consultations with antibiotics prescribed
3. Occurrence of RTI complications
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Sources of funding
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The Wellcome Trust (UK) (grant ref: 086921)
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Trial website
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Publications
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1. 2011 protocol in http://www.ncbi.nlm.nih.gov/pubmed/21569237
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Contact name
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Prof
Martin
Gulliford
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Address
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Division of Health and Social Care Research
Division of Primary Care and Public Health
King's College London
6th Floor Capital House
42 Weston Street
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City/town
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London
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Zip/Postcode
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SE1 3QD
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Country
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United Kingdom
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Email
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martin.gulliford@kcl.ac.uk
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Sponsor
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The Wellcome Trust (UK)
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Address
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Gibbs Building
215 Euston Road
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City/town
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London
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Zip/Postcode
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NW1 2BE
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Country
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United Kingdom
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Email
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contact@wellcome.ac.uk
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Sponsor website:
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http://www.wellcome.ac.uk/
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Date applied
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16/03/2010
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Last edited
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19/05/2011
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Date ISRCTN assigned
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17/03/2010
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