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Drivers of eating behaviour during chronic overconsumption
DOI 10.1186/ISRCTN47291569
ClinicalTrials.gov identifier
EudraCT number
Public title Drivers of eating behaviour during chronic overconsumption
Scientific title Drivers of eating behaviour during chronic overconsumption: role of food hedonics (liking and wanting) and peptide biomarkers on satiation and satiety
Acronym N/A
Serial number at source BB/G530141/1
Study hypothesis The aim of this study follows on from the findings of our previous BBSRC grant (BBS/B/05079: “The impact of physical activity on appetite control”). Participants are involved in two concurrent sub-studies. Study 1, looks at changes at energy balance over the duration of the intervention. Study 2 looks at the kinetics of gut peptides after consumption of breakfast. During the exercise intervention in study 1, a proportion of participants are expected to show compensatory increases in energy intake which will offset the energy deficit. This ‘relative overconsumption’ is safe because it does not result in significant weight gain, but does confer other health benefits such as increased fitness, lowered blood pressure, resting heart rate and reduced waist circumference (a marker of visceral fat).

The principal objective of the study is to characterise and compare those participants who lose the amount of weight predicted by their exercise expenditure (based on measured changes in their fat and lean mass) with those participants who do not lose the amount of weight predicted.

The outcomes of the study will yield important information about the processes that underpin eating behaviour during a prolonged elevation in food intake (relative overconsumption) in response to an increase in energy expenditure from exercise.
Lay summary Not provided at time of registration
Ethics approval UK National Health Service Research Ethics Committee Leeds (West) approved on the 20th January 2009 (ref: 09/H1307/7)
Study design SIngle centre medium term (12-week) experimental controlled study
Countries of recruitment United Kingdom
Disease/condition/study domain Overweight, obesity
Participants - inclusion criteria 1. 18 - 55 years old
2. Sedentary lifestyle (no leisure-time physical activity in previous 6 months)
3. Body Mass Index (BMI) between 27 - 38 kg/m2 or 18 - 23 kg/m2 (lean control)
4. Signed consent given
5. No objection from participant's GP
Participants - exclusion criteria 1. Inability to fully comply with intervention or study procedures
2. Insufficient English language skills to complete all questionnaires
3. Pre-existing injuries or conditions that could be aggravated by regular physical activity
4. Medication that could influence accumulation or expenditure of energy
5. Cardiac problems (arrhythmia, Congestive heart disease)
6. Uncontrolled hypertension
7. Genetic syndromes associated with obesity
8. Presence of untreated hypothyroidism
9. Recent body weight change (± 2 kg in previous 3 months)
10. Currently following weight loss regime
11. Food allergies or aversions
Anticipated start date 28/01/2008
Anticipated end date 29/10/2015
Status of trial Ongoing
Patient information material Not available in web format, please use contact details below to request a patient information sheet
Target number of participants 78
Interventions Supervised exercise to expend 500 kcal 5 times/week for 12 weeks. Assessments at week 0, week 6 and week 12. No exercise overweight/obese and lean comparators.
Primary outcome measure(s) Study 1:
Change in energy balance from week 0 to week 12 measured by the product of the energy cost of a unit change in fat mass by the observed change in fat mass and summing it with the product of the energy cost of a unit change in lean mass by the observed change in lean mass.

Study 2:
Rise and fall in concentration of gut peptides assayed from the participants’ blood samples in the four hour period following consumption of breakfast.
Secondary outcome measure(s) Study 1:
1.1. Cardiovascular fitness at week 12 will be measured by VO2 maximal test of aerobic capacity
1.2. Resting heart rate and Blood pressure at week 12 will be measured by an integrated digital blood pressure and heart rate monitor with inflatable cuff
1.3. Resting metabolic rate at week 12 will be measured by Gas Exchange Measurement
1.4. Substrate oxidation at week 12 will be measured by indirect calorimetry
1.5. Eating behaviour at week 12 will be measured by intake of test meals designed to vary in macronutrient composition (20:65:15 and 35:50:15, % carbohydrate:fat:protein) and quantitative ratings of hunger and satiety by questionnaire

Study 2:
Quantitative ratings of hunger and satiety by questionnaire.
Sources of funding Biotechnology and Biological Sciences Research Council (BBSRC) (UK) - (ref: BB/G530141/1)
Trial website
Publications 1. 2011 results in http://www.ncbi.nlm.nih.gov/pubmed/21651803
2. 2012 results in http://www.ncbi.nlm.nih.gov/pubmed/21733267
3. 2013 results in http://www.ncbi.nlm.nih.gov/pubmed/23193010
Contact name Prof  John  Blundell
  Address Institute of Psychological Sciences
University of Leeds
  City/town Leeds
  Zip/Postcode LS2 9JT
  Country United Kingdom
Sponsor University of Leeds (UK)
  Address c/o Rachel De Souza
  City/town Leeds
  Zip/Postcode LS2 9JT
  Country United Kingdom
  Sponsor website: http://www.leeds.ac.uk/
Date applied 14/09/2010
Last edited 15/03/2013
Date ISRCTN assigned 27/01/2011
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