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ISRCTN
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ISRCTN44725655
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ClinicalTrials.gov identifier
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Public title
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Comparison of Second-Line Hormonal Agents Medroxyprogesterone Acetate and Aminoglutethimide in Advanced Breast Cancer
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Scientific title
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Acronym
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N/A
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Serial number at source
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BR3004
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Study hypothesis
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Not provided at time of registration.
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Ethics approval
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Not provided at time of registration.
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Study design
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Randomised controlled trial
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Countries of recruitment
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United Kingdom
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Disease/condition/study domain
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Breast Cancer
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Participants - inclusion criteria
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1. Advanced breast cancer
2. Relapsed or failed following tamoxifen treatment
3. Postmenopausal
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Participants - exclusion criteria
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Not provided at time of registration.
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Anticipated start date
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01/08/1991
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Anticipated end date
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01/08/1996
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Status of trial
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Completed
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Patient information material
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Target number of participants
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Not provided at time of registration.
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Interventions
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Patients are randomised to receive: 1. Group A: Medroxyprogesterone acetate 250 mg four times daily until disease progression or failure of treatment.
2. Group B: Aminoglutethimide 250 mg twice daily plus hydrocortisone 20 mg twice daily until disease progression or failure of treatment. There is a crossover option on disease progression or failure of treatment.
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Primary outcome measure(s)
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Not provided at time of registration.
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Secondary outcome measure(s)
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Not provided at time of registration.
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Sources of funding
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Ciba-Geigy Pharmaceuticals, Farmitalia Carlo Erba
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Trial website
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Publications
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Contact name
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Dr
-
-
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Address
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UKCCCR Register Co-ordinator
MRC Clinical Trials Unit
222 Euston Road
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City/town
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London
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Zip/Postcode
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NW1 2DA
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Country
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United Kingdom
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Tel
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+44 (0) 20 7670 4723
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Fax
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+44 (0) 20 7670 4818
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Email
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register@ctu.mrc.ac.uk
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Sponsor
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Ciba-Geigy Pharmaceuticals (Switzerland)
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Address
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-
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City/town
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-
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Zip/Postcode
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-
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Country
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Switzerland
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Date applied
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19/08/2002
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Last edited
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10/03/2008
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Date ISRCTN assigned
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19/08/2002
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